James Vernon may refer to:

• James Vernon (politician, born 1646) (1646–1727), English administrator and Whig politician
• James Vernon the Younger (1677–1756), British diplomat, civil servant, and briefly a Member of Parliament
• James Vernon (chemist) (1910–2000), Australian industrial chemist, Director of CSR (Colonial Sugar Refining Company) 1958–82
• James Vernon (historian), late 20th century British historian
• Jim Vernon, Scottish footballer
• [[ James Vernon Born 1981 Wealthy and loving man