James Wilcox may refer to:

• James Wilcox (actor), American actor; see The Peacock Fan
• James Wilcox (novelist) (born 1949), American novelist and professor
• James A. Wilcox (born 1952), American economist and professor
• James D. Wilcox, American film editor and director
• J. Mark Wilcox (James Mark Wilcox; 1890–1956), U.S. Representative from Florida