In 2001, Joe's predecessor 4fm was launched. Together with Q-music, it was the first commercial radio station to be licensed as a national broadcaster in the Flemish Community. The station was purchased by Talpa Media in 2005. In May 2007, 4fm was taken over by DPG Media - then known as the Vlaamse Media Maatschappij. In 2008, 4fm started broadcasting a news-focused breakfast show named 4fm actueel that was simulcast on KANAALTWEE, owned by former Joe owner, Medialaan.^[2] It was axed a few months later.

On 19 February 2009, the hosts of 4fm announced that the station would relaunch as Joe FM on 1 April 2009. The station's format largely stayed the same. On Saturdays and Sundays, a show called Joekes broadcast excerpts of standup sets and comedy skits. In August 2012, Joe FM changed its slogan to Your Greatest Hits and implemented several new programmes.^[3]

Joe broadcasts in the Flemish Community (Flanders and Brussels) on the following frequencies:

• Aalst: 104.2 MHz
• Antwerp: 103.4 MHz
• Beringen: 98.4 MHz
• Bree: 93.5 MHz
• Brussegem: 95.6 MHz
• Brussels: 103.4 MHz
• Dendermonde: 92.2 MHz
• Diest: 103.3 MHz
• Egem: 104.1 MHz
• Geel: 93.5 MHz
• Genk: 103.4 MHz
• Ghent: 92.8 MHz
• Herzele: 90.9 MHz
• Heusden-Zolder: 88.8 MHz
• Holsbeek: 90.3 MHz
• Kasterlee: 91.4 MHz
• Leuven: 99.7 MHz
• Lommel: 103.7 MHz
• Mechelen: 96.7 MHz
• Ninove: 99.7 MHz
• Sint-Niklaas: 93.5 MHz
• Sint-Pieters-Leeuw: 95.5 MHz
• Sint-Truiden: 89.2 MHz
• Temse: 93.5 MHz
• Tongeren: 89.1 MHz
• Turnhout: 90.6 MHz
• Wuustwezel: 103.7 MHz

The station is also available via digital TV and online streams.