The campus was opened in 1951 and eventually it would host a great part of the old faculty of sciences of the Sorbonne. The campus is built on the site of the former "Halle aux Vins," a wine market created by Napoleon Bonaparte. In 1957, the first university buildings were built along the Eastern bank of the River Seine (le quai Saint-Bernard), and Rue Cuvier. In order to allow the wine market to remain on the site, the architects planned to construct the buildings on stilts above the roads of the market.

However, in 1964, with over 20,000 science students graduating high school (the baby boom generation), the old Sorbonne could not accommodate the influx of students. The Minister of Culture André Malraux entrusted architect Édouard Albert with the task of rapidly constructing a new science campus on the site. Albert's grand vision^{[citation needed]} of modular metallic buildings, designed to facilitate interdisciplinary work and improve teaching, was never achieved, and eventually abandoned in 1972.

Most of the campus consists in a regular grid of 6-floor wings; at the intersections are staircases and elevators. The grid is built above a large elevated slab; the buildings do not reach to the bottom of the slab, making it possible to walk across campus while remaining outdoors. Underneath the slab are ground-level and underground facilities, including a car park. The main front of Jussieu is bounded by a dry moat 10 meters deep; the main pedestrian entrance is a bridge over this moat that can be readily secured. The high-security features of the campus are likely^{[citation needed]} a response to the student riots that occurred in 1968 in this neighbourhood.

The center of the campus is a skyscraper called Tour Zamansky, or Tour Jussieu, housing the university's administrative offices. Its height is 24 floors or 90 meters.

Some of the campus' research libraries (in mathematics, for instance) are among the largest and with the widest selection of books in France. Campus restaurants are located in the northeast corner of the campus, many of which afford a pleasant view of the Seine River.

The campus was often decried as an architectural failure.^{[citation needed]} The hollow space under the building wings enables wind to build up its force, and thus the environment on the slab is unfriendly. Sound-proofing is very poor, with classes regularly having to briefly stop when someone flushes the toilet next door. The regular grid plan is confusing, and only long-time residents can move through without going back to the wind-blown ground level, since many corridors do not allow through-crossing (laboratories etc. have often chosen to lock their corridor for safety reasons). The campus had increasingly deteriorated since its construction, and its older tower stairwells and exteriors were covered in perpetual graffiti.

The most worrisome aspect of the Jussieu architecture was its extensive use of asbestos as a fire retardant. Asbestos fibers are carcinogenic when inhaled. As a consequence, the use of asbestos in buildings is prohibited in France, but was not at the time when the campus was built. The risks are particularly acute for workers who maintain the building (drilling walls, for example). In addition, the fire retardation is not considered sufficient, so that its metal frames would collapse in a large fire. An ambitious clean-up program was begun in 1997 after some high-profile protests. The wings are stripped of all equipment, walls, etc., down to the naked concrete frame, and are then rebuilt using more modern materials. Many advocated the destruction of Jussieu when the asbestos problem was addressed. However, the campus is protected as an architectural type, and must be restored to its original condition.

In 1996 Claude Allègre, a well known French politician and former scientist, opposed the removal of asbestos from the campus, describing it as harmless and dismissing concerns about it as a form of "psychosis created by leftists".^[1] The campus' asbestos is deemed to have killed 22 people and caused serious health problems in 130 others.^[2]

The 1997–2016 refurbishment completely removed the asbestos. This was also an opportunity to rebuild the campus to be more friendly to its inhabitants. The graffiti were removed; sound proofing and thermal isolation was added; many of the round stairwells were replaced by straight ones; openings were made to create vistas and let in light; the prefabs were destroyed and replaced by gardens; courtyards were covered by transparent roofing; a dry garden was created around the Zamansky building; and a restaurant was opened in the South-East courtyard.

The campus is served by the Paris Métro station Jussieu, as well as numerous bus lines.

• List of tallest buildings and structures in the Paris region

• Sites historiques: Campus Jussieu (in French)
• HISTORIQUE DU CAMPUS JUSSIEU (in French)

48°50′49″N 2°21′23″E / 48.846971°N 2.356333°E / 48.846971; 2.356333