KIF18A Knowpia

KIF18A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LRE
Identifiers
Aliases	KIF18A, MS-PPP1R99, kinesin family member 18A
External IDs	OMIM: 611271 MGI: 2446977 HomoloGene: 41820 GeneCards: KIF18A
Gene location (Human)
Chr.	Chromosome 11 (human)
End	28,108,156 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	109,172,092 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ganglionic eminence; ; sperm; ; testicle; ; stromal cell of endometrium; ; bone marrow; ; spongy bone; ; rectum; ; bone marrow cells; ; lymph node;
	Top expressed in
	secondary oocyte; ; spermatid; ; spermatocyte; ; medial ganglionic eminence; ; otic placode; ; maxillary prominence; ; abdominal wall; ; morula; ; primitive streak; ; somite;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; microtubule motor activity; tubulin-dependent ATPase activity; microtubule binding; microtubule plus-end binding; protein binding; actin binding; plus-end-directed microtubule motor activity; ATP binding; ATPase activity;
Cellular component	cytoplasm; cytosol; cell projection; kinetochore microtubule; kinesin complex; ruffle; microtubule cytoskeleton; microtubule organizing center; mitotic spindle midzone; caveola; microtubule; cytoskeleton; nucleus; kinetochore; mitotic spindle astral microtubule;
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II; male meiotic nuclear division; regulation of microtubule cytoskeleton organization; microtubule-based movement; seminiferous tubule development; protein transport; microtubule depolymerization; mitotic metaphase plate congression; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; cellular response to estradiol stimulus; mitotic sister chromatid segregation;
	Sources:Amigo / QuickGO
Orthologs
	81930
	228421
	ENSG00000121621
	ENSMUSG00000027115
	Q8NI77
	Q91WD7
	NM_031217
	NM_139303
	NP_112494
	NP_647464
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin family member KIF18A is a human protein encoded by the KIF18A gene.^[5]^[6] It is part of the kinesin family of motor proteins.

Function edit

KIF18A is a plus-end directed motor protein, and migrates to the plus ends of the spindle during early mitosis. It first accumulates there during prophase and metaphase, and is depleted during anaphase.^[7]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000121621 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027115 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
^ "Entrez Gene: KIF18A kinesin family member 18A".
^ Mayr MI, Hümmer S, Bormann J, Grüner T, Adio S, Woehlke G, Mayer TU (March 2007). "The Human Kinesin Kif18A Is a Motile Microtubule Depolymerase Essential for Chromosome Congression". Current Biology. 17 (6): 488–498. Bibcode:2007CBio...17..488M. doi:10.1016/j.cub.2007.02.036. ISSN 0960-9822. PMID 17346968.