The Kerala State Film Award for Second Best Actress was an award presented annually from 1969 to 2014 at the Kerala State Film Awards of India. The Kerala State Film Awards is managed by the Kerala State Chalachitra Academy, an autonomous non-profit institution working under the Department of Cultural Affairs, Government of Kerala. The award was discontinued in 2014 and was succeeded by the Kerala State Film Award for Best Character Actress from 2015 onwards.

Kerala State Film Award for Second Best Actress
K. P. A. C. Lalitha, one of most Awarded personality in this category is also a winner of National Film Award for Best Supporting Actress
Awarded for	Best performance by an actress in a Malayalam film
Sponsored by	Kerala State Chalachitra Academy
First awarded	1969
Last awarded	2014
Most winner	Kaviyoor Ponnamma (4) Sukumari (4) K. P. A. C. Lalitha (4)
Highlights
Total awarded	46
First winner	Adoor Bhavani
Last winner	Sethulekshmi