The Khedivial Opera House or Royal Opera House (Arabic: دار الأوبرا الخديوية / ALA-LC: Dār Awbirā al-Khudaywī) was an opera house in Cairo, Egypt, the oldest opera house in all of Africa. It was inaugurated on 1 November 1869 and it burned down on 28 October 1971.

The opera house was built on the orders of the Khedive Ismail to celebrate the opening of the Suez Canal. The Italian architect Pietro Avoscani (perhaps assisted by one Mario Rossi) designed the building. It seated approximately 850 people and was made mostly of wood. It was located between the districts of Azbakeya and Ismailyya in Egypt's capital city.

Verdi's opera Rigoletto was the first opera performed at the opera house on 1 November 1869. Ismail planned a grander exhibition for his new theatre. After months of delay due to the outbreak of the Franco-Prussian War, Verdi's new opera, Aida (set in the Old Kingdom of Egypt), received its world premiere at the Khedivial Opera House on 24 December 1871.

In the early morning hours of 28 October 1971, the opera house burned to the ground. The all-wooden building was quickly consumed, and only two statues made by Mohamed Hassan survived.

After the original opera house was destroyed, Cairo was without an opera house for nearly two decades until the opening of the new Cairo Opera House in 1988.

The site of the Khedivial Opera House has been rebuilt into a multi-story concrete car garage. The square (to the south of Al Ataba metro station) overlooking the building's location, is still called Opera Square (Meidan El Opera)