Konoe Hisatsugu (近衛 尚嗣, 1622 – 1653), son of regent Nobuhiro, was a kugyō or Japanese court noble of the Edo period (1603–1868). He held a regent position kampaku from 1651 to 1653.

His mother was not recorded. His sister was the consort of Tokugawa Mitsukuni, the daimyō of Mito Domain. As a son of Nobuhiro, he was a grandson of Emperor Go-Yōzei. His consort was Second Princess (Onna-ni-no-miya), the third daughter of Emperor Go-Mizunoo, thus a cousin of Hisatsugu. With her he had a daughter who was the consort of Fushimi-no-miya Prince Sadayuki (伏見宮貞致親王). With a servant he had a son, Motohiro.