LPAR4 Knowpia

LPAR4
Identifiers
Aliases	LPAR4, GPR23, LPA4, P2RY9, P2Y5-LIKE, P2Y9, lysophosphatidic acid receptor 4
External IDs	OMIM: 300086 MGI: 1925384 HomoloGene: 3871 GeneCards: LPAR4
Gene location (Human)
Chr.	X chromosome (human)
End	78,758,714 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	105,977,506 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; tibia; ; ganglionic eminence; ; Achilles tendon; ; monocyte; ; optic nerve; ; gastric mucosa; ; gallbladder; ; corpus callosum; ; smooth muscle tissue;
	Top expressed in
	dermis; ; pituitary stalk; ; primitive streak; ; trigeminal ganglion; ; tongue; ; left lung lobe; ; rib; ; vas deferens; ; abdominal wall; ; hand;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	lysophosphatidic acid binding; signal transducer activity; lipid binding; G protein-coupled receptor activity; lysophosphatidic acid receptor activity;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; plasma membrane; nuclear body; intracellular membrane-bounded organelle;
Biological process	signal transduction; positive regulation of Rho protein signal transduction; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2846
	78134
	ENSG00000147145
	ENSMUSG00000049929
	Q99677
	Q8BLG2
	NM_001278000; NM_005296
	NM_175271
	NP_001264929; NP_005287
	NP_780480
	Wikidata
View/Edit Human	View/Edit Mouse

Lysophosphatidic acid receptor 4 also known as LPA₄ is a protein that in humans is encoded by the LPAR4 gene.^[5]^[6]^[7] LPA₄ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).^[8]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147145 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049929 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GPR23 G protein-coupled receptor 23".
^ Janssens R, Boeynaems JM, Godart M, Communi D (July 1997). "Cloning of a human heptahelical receptor closely related to the P2Y5 receptor". Biochem. Biophys. Res. Commun. 236 (1): 106–12. doi:10.1006/bbrc.1997.6895. PMID 9223435.
^ O'Dowd BF, Nguyen T, Jung BP, Marchese A, Cheng R, Heng HH, Kolakowski LF, Lynch KR, George SR (March 1997). "Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes". Gene. 187 (1): 75–81. doi:10.1016/S0378-1119(96)00722-6. PMID 9073069.
^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

Further reading edit

Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". Biochim. Biophys. Acta. 1492 (1): 127–38. doi:10.1016/S0167-4781(00)00094-4. PMID 11004484.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Noguchi K, Ishii S, Shimizu T (2003). "Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family". J. Biol. Chem. 278 (28): 25600–6. doi:10.1074/jbc.M302648200. PMID 12724320.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147145 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049929 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GPR23 G protein-coupled receptor 23".

[pmid9223435-6] Janssens R, Boeynaems JM, Godart M, Communi D (July 1997). "Cloning of a human heptahelical receptor closely related to the P2Y5 receptor". Biochem. Biophys. Res. Commun. 236 (1): 106–12. doi:10.1006/bbrc.1997.6895. PMID 9223435.

[pmid9073069-7] O'Dowd BF, Nguyen T, Jung BP, Marchese A, Cheng R, Heng HH, Kolakowski LF, Lynch KR, George SR (March 1997). "Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes". Gene. 187 (1): 75–81. doi:10.1016/S0378-1119(96)00722-6. PMID 9073069.

[Choi_2010-8] Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

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Summary

See also edit

References edit

Further reading edit