After attending Vassar College for three years, Orthwein moved to New York City, became a Head Start Program teacher in the pilot program, having trained at the University of Puerto Rico. She also rose to Picket Captain in CORE (Congress of Racial Equality), attended New York University (NYU), and took graduate courses at Bank Street College of Education. Following her interests and research developed at Vassar College,^[3] she worked with the American Committee on Africa to welcome delegates from 17 newly independent states, 16 from Africa, join the UN and to picket Chase Manhattan Bank about their investments in South Africa. In 1963, she moved to Berkeley, California, and graduated from the University of California, Berkeley (UC-Berkeley), in 1971, having participated in the Free Speech Movement as well as other social justice movements.^[4] She participated in, and documented, 21 other social movements until 2020.^[2]

Laura X is the founder and was the director of the Women's History Research Center, in Berkeley, California, which was the first historical archive connected to the women's liberation movement.^[5][4] Laura X founded the Women's History Research Center in 1968. She organized a march in Berkeley, California, on International Women’s Day in 1969; International Women's Day had been largely forgotten in the United States before then.^[6] The march led to the creation of The Women’s History Research Center, a central archive of the women’s movement from 1968 to 1974.^[7] Laura X also thought it unfair for half the human race to have only one day a year and called for National Women's History Month to be built around International Women’s Day.^[8] The Women’s History Research Center collected nearly one million documents on microfilm, and provided resources and records of the women’s liberation movement that are now available through the National Women’s History Alliance, which carried on their ideas, including successfully petitioning Congress to declare March as Women’s History Month.^[9]

By 1970 the Women's History Research Center was widely listed in early feminist publications. The Center put many of the early feminist writings on microfilm, making them available in libraries across the country.^[5][10] The Women's History Research Center eventually closed, and its collections are now held in the women's history archive at the Schlesinger Library, which is part of Harvard University's Radcliffe Institute for Advanced Study, and at other institutions.^[10][11][12] The microfilm copies have been distributed through Primary Source Media/Cengage Learning to some 450 libraries in fourteen countries.^[13]

In 1977, Laura X became an associate of the Women's Institute for Freedom of the Press (WIFP).^[14] WIFP is an American nonprofit publishing organization. The organization works to increase communication between women and connect the public with forms of women-based media.^[15]

In 1978 the Women's History Research Center established the National Clearinghouse on Marital and Date Rape in Berkeley, California, with Laura X as director.^[16]

In 1979 Laura X led a successful campaign to make marital rape a crime in California.^[16] She also acted as a consultant to 45 other state campaigns on marital and date rape, as well as collecting and maintaining documents about the status of exemptions from prosecution in rape laws.^[16] Repeal of date and marital rape exemptions occurred in 45 states, in Federal and military law, in the laws of Guam and Puerto Rico, and the laws of twenty other countries.^[17]

As the leader of NCMDR’s campaign against marital rape, Laura X appeared on dozens of local and national TV and radio shows, including 60 Minutes, The Phil Donahue Show, Seattle Today, Sally Jessie Raphael, Geraldo, the Today Show, CBS News, and the Gary Collins show.^[18]

In September 1999 Laura X published her memoir "Accomplishing the Impossible: an Advocate's Notes from the Successful Campaign to Make Marital and Date Rape a Crime in All 50 U.S. States and Other Countries" in Violence Against Women: An International and Interdisciplinary Journal. ^[19][20]

As Laura Rand Orthwein, in 1959 she was Queen of the Veiled Prophet Ball in St. Louis, Missouri.^[21][22]

In recognition of her achievements, Laura X received

• Commendation by the American Library Association, 1971^[23]
• Woman of Achievement award (from Mademoiselle Magazine)^[24]
• World Congress of Victimology Award for Innovative Programs and Services.^[25][26]
• Commendation Surgeon General C. Everett Koop, 1985.^[17]
• In 2009, Laura X was honored by the University of Missouri St. Louis (UMSL) with the Trailblazers Award.^[27]