Levodropropizine

Summary

Levodropropizine is a cough suppressant. It is the levo isomer of dropropizine. It acts as a peripheral antitussive, with no action in the central nervous system.[1] It does not cause side effects such as constipation or respiratory depression which can be produced by opioid antitussives such as codeine and its derivatives.

Levodropropizine
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Pharmacokinetic data
Protein binding11-14%
Excretion83% via urine within 96 h
Identifiers
  • (2S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol
CAS Number
  • 99291-25-5 checkY
PubChem CID
  • 65859
DrugBank
  • DB12472 checkY
ChemSpider
  • 59270 checkY
UNII
  • 3O31P6T4G3
KEGG
  • D08119 checkY
ChEBI
  • CHEBI:82722 ☒N
CompTox Dashboard (EPA)
  • DTXSID8023210 Edit this at Wikidata
ECHA InfoCard100.167.719 Edit this at Wikidata
Chemical and physical data
FormulaC13H20N2O2
Molar mass236.315 g·mol−1
3D model (JSmol)
  • Interactive image
  • O[C@@H](CN2CCN(c1ccccc1)CC2)CO
  • InChI=1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2/t13-/m0/s1 checkY
  • Key:PTVWPYVOOKLBCG-ZDUSSCGKSA-N checkY
 ☒NcheckY (what is this?)  (verify)

References edit

  1. ^ De Blasio F, Dicpinigaitis PV, Rubin BK, De Danieli G, Lanata L, Zanasi A (January 2012). "An observational study on cough in children: epidemiology, impact on quality of sleep and treatment outcome". Cough. 8 (1): 1. doi:10.1186/1745-9974-8-1. PMC 3274450. PMID 22269875.