Lexington Avenue is an avenue on the East Side of Manhattan in New York City.

Lexington Avenue may also refer to:

• Lexington Avenue–63rd Street (63rd Street Lines), serving the F and <F>​, N, ​Q, and ​R trains
• Lexington Avenue/59th Street (BMT Broadway Line), serving the N, ​R, and ​W trains
• Lexington Avenue-53rd Street (IND Queens Boulevard Line), serving the E and ​M trains
• IRT Lexington Avenue Line, the east side trunk line serving the 4, ​5, ​6, and <6> trains
• Lexington Avenue (Asheville, North Carolina)