Licarbazepine is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects that is related to oxcarbazepine.[1] It is an active metabolite of oxcarbazepine.[1][2] In addition, an enantiomer of licarbazepine, eslicarbazepine ((S)-(+)-licarbazepine), is an active metabolite of eslicarbazepine acetate.[1][2] Oxcarbazepine and eslicarbazepine acetate are inactive on their own, and behave instead as prodrugs to licarbazepine and eslicarbazepine, respectively, to produce their therapeutic effects.[1][2]
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Pharmacokinetic data | |
Protein binding | <40% |
Metabolites | Glucuronides |
Excretion | Mainly renal |
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ECHA InfoCard | 100.122.427 |
Chemical and physical data | |
Formula | C15H14N2O2 |
Molar mass | 254.289 g·mol−1 |
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Chirality | Racemic mixture |
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