The GNOME Project, i.e. all the people involved with the development of the GNOME desktop environment, is the biggest contributor to GTK, and the GNOME Core Applications as well as the GNOME Games employ the newest GUI widgets from the cutting-edge version of GTK and demonstrates their capabilities.

• GNOME Shell – the desktop graphical GUI shell introduced with GNOME version 3.0
• Cinnamon fork of the GNOME Shell
• GNOME Panel and forks – applications launcher
• Maynard, a shell for Weston by Collabora originally for the Raspberry Pi
• Budgie is a distro-agnostic desktop environment

• Tux Typing – typing tutor for children
• DrGeo – geometry software
• GCompris – educational entertainment for children (legacy version only)

Operating system administration edit

• Disk Usage Analyzer – Disk-usage analyzer
• GNOME Disks – utility for the hard disk; partition editor, S.M.A.R.T. monitoring, formerly known as Gnome Disk Utility or palimpsest
• GParted – utility for the hard disk; partition editor
• GDM – X display manager
• GNOME Keyring Manager – Password manager
• GNOME Screensaver – Simple screensaver configuration
• Alacarte – Menu editor

End-user utilities edit

• Archive Manager – archive manager
• Cheese – webcam application
• Conduit Synchronizer – Photo/music/notes/files etc. synchronization
• Eye of GNOME – official image-viewer for GNOME
• Getting Things GNOME! – Personal tasks management software
• gnee – A GNOME GUI and a panel applet that can be used to record and replay test cases.
• GNOME Boxes – Application to access remote or virtual systems
• GNOME Screenshot – take screenshots of desktop and windows
• GNOME Calculator – calculator
• GNOME Commander – Two-panel graphical file manager
• GNOME Files – File manager, formerly called Nautilus
• GNOME Terminal – Terminal emulator
• Gnote – Note-taking software in C++
• Guake – drop-down terminal emulator^[1][2]
• Gucharmap – Character map
• Guvcview – webcam application
• Orca – Scriptable screen-reader
• Scribes – Text editor
• Seahorse – PGP and SSH key-manager
• Sushi – File previewer
• Terminator - Terminal emulator
• Tilda – drop-down terminal emulator^[3][4][5][6]
• Tomboy – Note-taking software in C#
• Vinagre – VNC client
• Vino – VNC server (deprecated)

• GNOME Games – collection of games in Vala and C, now archived
• Lutris - video game manager/launcher

Abstract strategy games edit

• GNOME Chess – new 2d graphical front-end written in Vala
• PyChess – Chess implementation

Puzzle games edit

• GNOME Mines – Minesweeper-clone
• gbrainy – Brain teaser game

Graphics editors edit

• GIMP – an extensive raster graphics editor
• Inkscape – an extensive vector graphics editor
• MyPaint – an extensive raster graphics editor, for digital painters
• Pinta – a minimalist raster graphics editor

Image viewers edit

• Shotwell – Photo manager
• F-Spot – Photo manager
• gThumb – Image viewer

Web browsers edit

• Web – default GNOME web-browser
• Midori – default Xfce web-browser
• Uzbl – minimalist web-browser
• xombrero – minimalist web-browser

Email clients edit

• Balsa – Email client
• Claws Mail
• Evolution (software)
• Geary
• Modest (email client)
• Pantheon Mail
• Sylpheed

Software for inter-person communication edit

• Empathy – instant-messaging client, VoIP and videoconferencing
• Pidgin – Instant messenger
• Smuxi – User-friendly IRC Client
• HexChat – IRC client
• Gajim – Instant messenger

File sharing edit

• Deluge — BitTorrent client
• Transmission – BitTorrent client
• Gwget – Download manager framework
• Gwibber – Microblogging client
• Liferea – RSS feed reader
• Pan – Usenet news reader

• AbiWord – word processor
• GnuCash – Personal and small business finance manager
• Gnumeric – Spreadsheet
• BOND – Database frontend
• Evince – pdf viewer
• GNOME Dictionary – Dictionary
• Evolution – Integrated mail, contacts, and calendar
• OCRFeeder – a graphical front-end for the Optical character recognition engines CuneiForm, GOCR, Ocrad and Tesseract

• GNOME Builder – Integrated development environment
• Anjuta – Integrated development environment
• Glade Interface Designer – a Graphical user interface builder
• Gedit – Text editor
• Leafpad – Lightweight text editor
• Lazarus - cross-platform visual IDE for RAD using the Free Pascal compiler
• Devhelp – API documentation browser
• Nemiver – C and C++ debugger
• Geany – text editor suitable for programming
• Meld – diff-viewer
• PIDA – IDE
• Xojo – IDE
• Zenity – execute GTK dialog boxes from shell scripts
• MonoDevelop – Integrated development environment
• ActiveState Komodo – Integrated development environment
• Gtranslator – uses gettext
• poedit – gettext
• Scala (software)

Optical disc authoring software edit

• Brasero – optical disc authoring software, graphical front-end to burn CDs/DVDs

Optical disc ripping software edit

• Grip – CD ripper and player
• Thoggen – DVD backup utility

• Software audio players (free and open-source)
• SoundConverter (software)
• GNOME Sound Juicer

Video players edit

• GNOME Videos – the GNOME default video player

Video editors edit

• Gnome Subtitles – Video subtitling
• Pitivi – Video editor
• Cinelerra - Video editor

Chemistry edit

Despite the immense popularity of Qt, there continues to be science software using the GUI widgets of version 2 of GTK toolkit. Whether this is going to remain that way, or whether the software will be ported to some current version of GTK (maybe GTK 4) remains to be seen.

• Ghemical – computational chemistry software package

Statistics edit

• gretl — an open-source statistical package, mainly for econometrics

• Beagle – search tool
• Gramps – Genealogy software

• List of free electronics circuit simulators