This is a list of recording artists who have reached number one on the singles chart in Italy since Federazione Industria Musicale Italiana (FIMI) began reporting charts on 4 January 1997.

• All acts are listed alphabetically.
• Solo artists are alphabetized by last name, Groups by group name excluding "A", "An", and "The".
• Each act's total of number-one singles is shown after their name.
• All artists who are mentioned in song credits are listed here; this includes one-time pairings of otherwise solo artists and those appearing as featured. Members of a group who reached number one are excluded, unless they hit number one as a solo artist.