The early people of Bulacan, had also risen in revolt as in other parts of the country. Bulacan was one of the eight provinces, which rallied behind the Katipunan's call for an all-out insurrection against the Spanish occupation in the late 19th century.

• Marcelo H. del Pilar (Kupang, San Nicolas, Bulakan) – the "Great Propagandist" of the Philippine Propaganda Movement; editor in chief of Diariong Tagalog and La Solidaridad.
• General Gregorio del Pilar (San Jose, Bulakan) – Marcelo H. del Pilar's nephew, one of the youngest revolutionary generals during the Philippine Revolution and the Philippine–American War, died at the Battle of Tirad Pass.
• Mariano Ponce (Baliwag) – physician, Propagandist
• Pío Valenzuela (Polo) – physician, Katipunan leader, established Katipunan branches in Morong and Bulacan; co-founded "Kalayaan", the Katipunan newsletter; emissary of Andrés Bonifacio to José Rizal
• Trinidad Tecson (San Miguel de Mayumo) – female Katipunan revolutionary
• Felipe Buencamino, Sr. (San Miguel de Mayumo) – revolutionary, co-writer of the Constitution of the Philippine Republic at Malolos
• Commodore Ramon A. Alcaraz (Plaridel) – World War II veteran, Captain of Q-boat 112 ABRA Shot down 3 Japanese Zero fighters
• Gat Ciriaco Contreras (Meycauayan) – Defended the Barrio of Langka and commanded the katipuneros of year 1898 against the Spaniards, one of the foundations of Bulacan alongside the Supremo Gat Andres Bonifacio. Also one of the Commanding Officers of the Supremo.
• General Nicolas Capistrano (Angat) – lawyer, statesman and revolutionary general who fought against Americans in Cagayan de Misamis (now Cagayan de Oro) in Mindanao during Philippine-American War, notably the battles of Cagayan de Misamis, Agusan Hill and Macahambus Hill, all in 1900. He entered politics as a 2nd district congressman of then-undivided Misamis Province (1909-1912) and a senator of newly established 11th district shared with Jose Clarin, making him one of the most prominent men in what is now Cagayan de Oro, where he and his wife migrated to after 1895 to avoid arrest by the Spanish colonial government for his involvement in revolutionary activities and to start a new life there.

Bulacan is also home to many of the country's greatest artists, with a good number elevated as National Artists.

• Katy de la Cruz (Bustos) – tagged as the Queen of Filipino Jazz and Bodabil
• Hermogenes Ilagan (Balagtas) – tenor, writer, stage actor, and playwright known as the Father of Philippine Zarzuela
• Francisco Balagtas, also known as or Francisco Baltazar (Panginay, Bigaa) – writer, author of Florante at Laura.
• Jose Corazon de Jesus (pen name "Huseng Batute"; Santa Maria, his father's hometown) – poet
• Basilio L. Sarmiento (Meycauayan) – poet
• Isidro Ancheta (San Miguel) – painter
• Constancio Bernardo (Obando) – painter and professor known for making the earliest modern geometric abstract paintings in the Philippines and in Southeast Asia.
• Nicanor Abelardo (San Miguel) – prolific composer of kundimans
• Francisco Santiago (Santa Maria) – kundiman composer
• Enya Gonzalez (Baliwag) – opera singer
• Cecile Licad – concert pianist, descendant of Francisco Buencamino
• Jess Santiago (Obando) – poet, songwriter, singer-composer, protest musician
• Rey Valera (Meycauayan) – singer, songwriter, music director, scorer
• Narcisa Doña Sisang de Leon (San Miguel) – film producer for LVN Films
• Richard Velayo Abelardo, (San Miguel) – film director
• Michiko Yamamoto – screenwriter
• Carlos A. Santos-Viola (San Miguel) – architect known for designing churches for the Iglesia ni Cristo

The following artists were named as National Artists of the Philippines (listed in chronological order of membership):

• Francisca Reyes Aquino (Bocaue) – Dance (1973)
• Amado V. Hernández (Hagonoy) – Literature (1973, posthumous award)
• Guillermo Tolentino (Malolos) – Sculpture (1973)
• Gerardo de Leon – Film (1982)
• Honorata Atang dela Rama – Theater and Music (1987)
• Antonino Buenaventura (Baliwag) – Music (1988)
• Levi Celerio (Baliwag) – Music and Literature (1997)
• Ernani Cuenco – Music (2000, posthumous)
• Virgilio S. Almario (San Miguel) – Literature (2003)

• Geminiano T. De Ocampo (Malolos) – National Scientist of the Philippines for Ophthalmology
• Gregorio Velasquez (Calumpit) – National Scientist of the Philippines for Phycology
• Francisco O. Santos (Calumpit) – National Scientist of the Philippines for Human Nutrition and Agricultural Chemistry
• Virgilio Enriquez (Balagtas) – social psychologist known as Father of Filipino psychology "Ama ng Sikolohiyang Pilipino"

• Dionisia de Santa María Mitas Talangpaz (Calumpit) – Roman Catholic Servant of God, native of Calumpit with Kapampangan blood from Macabebe and a candidate for sainthood.
• Cecilia Rosa de Jesús Talangpaz (Calumpit) – Roman Catholic Servant of God, native of Calumpit with a Kapampangan blood from Macabebe and a candidate for sainthood, and the sister of Bl. Dionisia.
• Bishop Ruperto Cruz Santos (born in San Rafael, Bulacan, October 30, 1957) – fourth Bishop of Balanga (July 8, 2010–July 22, 2023) and fifth Bishop of Antipolo (July 22, 2023–present).
• Bishop Francisco San Diego (born in Obando, Bulacan, October 10, 1935) – Second Bishop of the Diocese of San Pablo, Laguna and First Bishop of the Diocese of Pasig, Metro Manila.
• Bishop Bartolome Gaspar Santos (born in Sta. Maria, Bulacan) – fifth Bishop of the Diocese of Iba, Zambales
• Bishop Deogracias S. Iñiguez, Jr. (born in Meycauayan, Bulacan, December 10, 1940) – former Auxiliary Bishop of the Diocese of Malolos and First Bishop of the Diocese of Kalookan.
• Bishop Pedro Bantigue y Natividad (born in Hagonoy, Bulacan) – former Auxiliary Bishop of the Roman Catholic Archdiocese of Manila and First Bishop of the Roman Catholic Diocese of San Pablo.
• Archbishop Artemio Gabriel Casas (born in Meycauayan, Bulacan, October 20, 1911) – first Bishop of the Diocese of Imus, former Auxiliary Bishop of the Archdiocese of Manila and the tenth Archbishop of the Archdiocese of Jaro.
• Archbishop Leonardo Zamora Legaspi (born in Meycauayan, Bulacan, November 25, 1935) – first Filipino Rector Magnificus of the University of Santo Tomas, former Auxiliary Bishop of the Archdiocese of Manila, Catholic Bishops' Conference of the Philippines President (1987–1991) and the 33rd Bishop and third Archbishop of the Archdiocese of Caceres.
• Bishop Amado Paulino y Hernandez, Bishop Antonino Francisco Nepomuceno, and Bishop Bienvenido Mercado Lopez – The "Tres Obispos" (3 Bishops) of Bustos. The first and only small town in the whole archipelago ever to produce 3 Catholic Clergy Bishops at the same time.
• Herminio Dagohoy, O.P. (Hagonoy) – 96th Rector Magnificus of the University of Santo Tomas (UST), the oldest and the largest Catholic university in Manila, Philippines.
• Sabino Vengco (Hagonoy) – Filipino priest, theologian, and author.
• Ma. Violeta Marcos, AMP (Pandi) – Filipino Roman Catholic nun best known as the co-founder and first director of the Augustinian Missionaries of the Philippines,^[1] and for her contributions to the resistance in opposition to the martial Law dictatorship of Ferdinand Marcos - first through her diocesan social action involvements in Negros Occidental,^[2] and later as part of the human rights organization Task Force Detainees of the Philippines.^[3]
• Daniel Razon (Calumpit) – Vice-Presiding Minister of Members Church of God International, chairman and CEO of Breakthrough and Milestones Productions International Inc., TV/Radio Host.
• Bro. Eddie Villanueva (Bocaue) – Spiritual Leader of Jesus Is Lord Church and Chairman ZOE Broadcasting Network.

• Corazon C. Aquino (Malolos) – 1st Female President, Father born in Malolos City member of rich Cojuangco Clan
• Joseph Ejercito Estrada (Malolos) – 13th President of the Republic
• Blas Ople (Hagonoy) – Senator, journalist, secretary of Labor and Foreign Affairs
• Francisco "Soc" Rodrigo (Bulakan) – Former senator, member of the Philippine Constitutional Commission of 1986
• Gen. Alejo Santos (Bustos) – governor, secretary of National Defense during the Garcia Administration.
• Lt. General Rafael Ileto (Salacot, San Miguel, Bulacan) – served as the 22nd Secretary of the Department of National Defense (DND) of the Philippines. He also became the Vice-Chief of Staff of the Armed Forces of the Philippines (AFP). He also served as Philippine Ambassador to Turkey, Iran, Cambodia, Thailand, and Laos, Father of the Scout Rangers (AFP).
• Cardozo Luna (San Ildefonso) – Undersecretary of Department of National Defense, former Philippine Ambassador to the Netherlands, former Vice Chief of Staff and Lieutenant General of the Armed Forces of the Philippines
• Francisco Afan Delgado (Malolos) – Resident Commissioner to the United States House of Representatives (74th Congress) from the Philippine Islands January 3, 1935 – February 14, 1936; Philippine Ambassador to the United Nations, September 29, 1958 – January 1, 1962
• Joel Villanueva (Bocaue) – currently Senator, Former TESDA Director General
• Albert del Rosario (Bulacan) – Former Philippine Ambassador the United States and Secretary of Foreign Affairs. Great grandparents hail from Bulacan, Bulacan and his great grandmother, Teresa Sempio is the sister of Felipa Sempio, mother of Gregorio del Pilar
• Mar Roxas (San Miguel) – his grandmother was a member of De Leon clan, a rich clan in San Miguel
• Imelda Marcos (Baliwag) – Ferdinand Marcos' First Lady
• Daniel Fernando (Guiguinto) – Actor and currently the Bulacan Governor
• Alex Castro (Marilao) – actor, singer, model, currently the Bulacan Vice-Governor
• Herbert Bautista (Malolos) – former Mayor of Quezon City
• Crispin Beltran (San Jose del Monte) – Party-List Representative Anak Pawis
• Jose Maria Delgado (Malolos) – first Philippine Ambassador to the Vatican.
• Roberto Pagdanganan (Calumpit) – former governor, secretary of Agrarian Reform and Tourism
• Carlito Galvez Jr. (Bustos) – former Chief of Staff of the Armed Forces of the Philippines (AFP) during the Duterte Administration. He is also known for his leadership of the AFP Western Mindanao Command during the Battle of Marawi.
• Luzviminda Tancangco – also known as "Baby"; first non-lawyer and woman commissioner of the Philippine Commission on Elections. She was also its first female acting chairman (1998–1999).
• Rear Admiral Hilario Ruiz – former Flag Officer in Command of the Philippine Navy; one of Rolex 12 advisers of President Ferdinand Marcos during his martial law period; BRP Hilario Ruiz (PG-378), a coastal patrol boat of the Philippine Navy, is named after him.
• Conrado Mercado, Sr. – locally known as "Mr. Irrigation"; first National Irrigation Administration (NIA) Assistant Administrator; Original owner of the Mercado Ancestral House in Brgy. Bonga Menor; the government created a statue for him to serve as a memorabilia for him and his contributions.
• Conrado Mercado, Jr. – most successful Bustosenyo in the aspect of arts; famous metal-sculptor and painter; one of the greatest artists produced by the University of Santo Tomas; enlisted as one of UST's Alumni Permanent Roll of Honor; gained the Outstanding Thomasian Award in the field of arts; honored by the City of Manila with the Patnubay ng Sining Award; founded the Philippine Association of Figure Artists and became the president of Society of Philippine Sculptors; his artworks are placed in the Paraiso ng mga Bata in front of the Aklatang Bayan ng Bustos being part of the Bustos Heritage Park.
• Minister Jesus Hipolito – former Minister of Department of Public Works and Highways from 1980-1986.
• Gen. Romeo Maganto – retired and decorated police general of the Philippine National Police having awarded with 45 medals in service; former chief of Western Police District; former traffic czar during the administration of President Fidel V. Ramos and is known as the first to implement the color coding traffic scheme in 1995; featured in the films Tomagan: Story of Gen. Romeo Maganto and Leon ng Maynila, Lt. Col. Romeo Maganto.

• Cheche Lazaro – TV host, and chairman and CEO of Probe Productions Inc.
• Joey de Leon (Malolos) – TV host (notably of Eat Bulaga!), comedian, singer, and songwriter
• Dely Magpayo ("Tita Dely") – radio host
• Cheryl Cosim (Hagonoy) – news anchor, reporter, radio broadcaster
• Mo Twister (San Rafael) – radio host

• Gemma Teresa Guerrero Cruz (Baliwag) – Miss International 1964
• Teresita Sanchez Toralba (Plaridel) – Miss Philippines Universe 1953
• Agnes Rustia (Baliwag) – Miss Philippines World 1976
• Maricar Balagtas (Plaridel) – Miss Philippines Universe 2004, Miss Globe 2000
• Czarina Catherine Gatbonton (Malolos) – Miss Philippines World 2010
• Riza Santos (Malolos) – Miss Earth Canada 2006, Miss World Canada 2011
• Michelle Aldana (Santa Maria) – Mutya ng Pilipinas 1993, Miss Asia Pacific Winner 1993
• Angelica Jasmine Reyes (Hagonoy) – Mutya ng Pilipinas 1992, Miss Asia Pacific Top 10 1994
• Rachell Soriano (Meycauayan) – Binibining Pilipinas World 1997, Miss World 1997