The following is a list of prominent people who were born in the U.S. state of South Carolina, lived in South Carolina, or for whom South Carolina is a significant part of their identity.
James F. Byrnes (1882–1972), born in Charleston; U.S. Representative, U.S. Senator, Justice of the Supreme Court, Secretary of State, and 104th governor of South Carolina.
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Pat Caddell (1950–2019), born in Rock Hill; public opinion pollster, political film consultant
Toy Caldwell (1947–1993), born in Spartanburg; lead guitarist and vocalist for the Marshall Tucker Band
Floride Calhoun (1792–1866), born in Charleston; Second Lady of the United States
John Caldwell Calhoun (1782–1850), born in Abbeville County; U.S. Senator, Secretary of State, Secretary of War, and the 7th Vice-President of the U.S.
Julius Dixson (1913–2004), born in Barnwell; songwriter and record company executive
Larry Doby (1923–2003), born in Camden; baseball player in Negro leagues and Major League Baseball, first black player in American League, later manager of Chicago White Sox, Hall of Fame inductee
Stanley Donen (1924–2019), born in Columbia; film director and choreographer
Ulysses Dove (1947–1996), born in Columbia; choreographer
David E. Finley Jr. (1890–1977), born in York, art executive, first director of the National Gallery of Art, founding chairman of the National Trust for Historic Preservation, and chairman of the United States Commission of Fine Arts
Lindsey Graham (born 1955), from Central, politician, lawyer, long-time South Carolina Senator since 2003, and unsuccessful 2016 presidential candidate
Boyce Green (born 1960), born in Beaufort, former running back in the National Football League
Arthur Middleton (1742–1787), born in Charleston, signer of the Declaration of Independence, Governor (1810–1812), Representative (1815–1819), and Minister to Russia (1820–1830)
Bill Pinkney (1925–2007), born in Dalzell, pitcher in the Negro leagues, served in World War II, performer and singer with The Drifters
Joel Roberts Poinsett (1779–1851), born in Charleston, Martin Van Buren's Secretary of War, physician, botanist, and statesman, as well as famous eponym
Tom Turnipseed (1936–2020), lived in Columbia; lawyer, executive director of the 1968 presidential campaign of George C. Wallace, former member of the South Carolina State Senate
James E. Williams (1930–1999), born in Fort Mill, raised in Darlington; Medal of Honor (Vietnam, 1966), highest decorated enlisted man in the history of the U. S. Navy, U. S. Marshal
Henry Woodward (1646–1690), an early colonist of South Carolina who was instrumental in establishing contact with Native Americans and setting up a trading system
W. D. Workman Jr. (1914–1990), newspaper and radio journalist, author;Republican nominee for the U.S. Senate in 1962 and for governor of South Carolina in 1982
^"Norman Armiitage, Fencing Star And Textile Executive, Dies at 65" - The New York Times
^Gilbey, Ryan (August 29, 2020). "Chadwick Boseman obituary". The Guardian. Retrieved August 29, 2020.
^Leigh Guidry (March 25, 2015). "LC board names South Carolina VP as ninth president". The Alexandria Town Talk. Retrieved July 23, 2015.
^Hutcheson, Susannah. "How I became an actress and advocate: Danielle Brooks". USA TODAY. Retrieved January 21, 2021.
^"Fiona Hutchison profile" Archived December 4, 2005, at the Wayback Machine. Soapcentral.com.
^Noden, Merrell (July 6, 1992). "Great Expectations: Melvin Stewart's Journey From the World of the PTL Ministry to his Life as the World's Best Butterflyer Has Been Well, Dickensian". Sports Illustrated. Retrieved July 20, 2021.
^"Where Are They Now?: Mel Stewart". Charlotte Magazine. July 20, 2010. Retrieved July 20, 2021.