Comedies edit

• 8 Out of 10 Cats (2017–present) (Also shown on E4 Extra)
• The Inbetweeners (2008–10)
• The Holden Girls: Mandy & Myrtle (2021-present)^[1]

Reality/non-scripted edit

• Body Fixers (2016–present)
• Coach Trip (2016–present)
• Celebs Go Dating (2016–present)
• Don't Tell the Bride (2017–present)
• First Dates Teens (2021-present)
• GamesMaster (2021–present)
• Gogglebox (repeated from Channel 4)
• Made in Chelsea (2011–present)
• Married at First Sight UK (2021–present) (moved from Channel 4 for series six)
• Naked Attraction (repeated from Channel 4)
• Pete & Sam's Reality News (2020-present)^[2]
• The Real Dirty Dancing (2022–present)
• Rude Tube (2008–2017, moved to E4 Extra)
• Street Dance: Against the Odds (2022–present)
• Teen Mum Academy (2022–present)

Channel 4 programming edit

• Hollyoaks (soap opera) (2001–present)

Acquired programming from North America (first run) edit

• Batwoman (29 March 2020–present)
• Below Deck Mediterranean (reality) (2021–present) (second run only) (first run rights are with Hayu)
• The Big Bang Theory (sitcom) (2008-present)
• Birdgirl (2021–present)
• Black-ish (sitcom) (2016–present)
• Charmed (fantasy drama) (2019–present)^[3][4]
• Fear the Walking Dead (post-apocalyptic drama) (2018–present)^[5] (also on AMC)
• The Goldbergs (sitcom) (2015–present)
• The Good Place (sitcom) (2018–present) (also available on Netflix)
• Harley Quinn (7 May 2020–present)
• Impractical Jokers (2023-present) (also on Comedy Central)
• Killing It (2022–present)
• Legendary (2021–present)
• Lego Masters USA (2021–present)
• Modern Family (2022-present) (moved from Sky Comedy and Sky Showcase)
• The Neighborhood (2022–present)
• 12 Dates of Christmas (from 13 December 2021)^[6]
• Rick and Morty (15 February 2019–present) (moved from TruTV and Comedy Central, also available on Netflix)
• Tuca & Bertie (2022) (No longer airing on E4, but still available on Channel 4 (VoD service))
• Summer House (2022–present) (second run only, also available on Hayu)
• Smiling Friends (2022–present)
• Teenage Euthanasia (2022-present)
• Robot Chicken (15 February 2019–present) (previously part of TruTV's Adult Swim Friday night line-up)
• Young Sheldon (sitcom) (2018–present)
• Wipeout USA (sports) (2021–present)
• Zoey's Extraordinary Playlist (musical) (2021–present)

Acquired programming from Australia (first run) edit

• First Dates Australia (reality) (2016–present)
• Gogglebox Australia (reality) (2018–present)
• Lego Masters Australia (2021–present)
• Married at First Sight Australia (2016–present)

Acquired programming (repeats) edit

• Mike & Molly (sitcom)^[7]
• Ramsay's Kitchen Nightmares USA (reality)

E4 comedies edit

• School of Comedy (2009–10)
• PhoneShop (2010–13)
• Beaver Falls (2011–12)
• Cardinal Burns (2012 Channel 4 2014)
• The Midnight Beast (2012–14)
• Noel Fielding's Luxury Comedy (2012–14)
• Drifters (2013–2016)
• Chewing Gum (2015–2017)
• Wasted (2016)
• Crazyhead (2016)
• Gap Year (2017)
• Dead Pixels (2019–2021)
• Maxxx (2020)

Acquired comedies edit

• 2 Broke Girls (sitcom)
• Angie Tribeca (sitcom)
• Baby Daddy (sitcom)
• Being Erica (comedy-drama)
• Happy Endings (sitcom)
• How I Met Your Mother (sitcom)
• Marry Me (sitcom)
• Rules of Engagement (sitcom)
• Speechless (sitcom)
• Suburgatory (sitcom)
• Young & Hungry (sitcom)

E4 dramas edit

• Skins (2007–13)
• Misfits (2009–13)
• My Mad Fat Diary (2013–15)
• Youngers (2013–14)
• Glue (2014)
• Tripped (2015)
• The Aliens (2016)

Acquired dramas edit

• 90210 (teen drama)
• Being Erica (comedy-drama)
• Charlie's Angels (drama)
• Charmed (fantasy-drama)
• Life Unexpected (drama)
• Make It or Break It (teen drama)
• Revenge (drama)
• Supernatural (fantasy-drama)
• The Tomorrow People (sci-fi drama)
• Veronica Mars (teen drama-mystery)

Reality/non-scripted edit

• Rude Tube (2008–2018, moved to 4Music)
• Dirty Sexy Things (2011)
• Playing It Straight (2011–2012)
• Tool Academy (2011–2012)
• Desperate Scousewives (2011–2012)
• What Happens in Kavos... (2013)
• Party House (2014)
• Troy (2014–2015)
• Virtually Famous (2014–2017)
• Tattoo Fixers (2015–2019)
• Young, Free and Single: Live (2015)
• Look Into my Eyes (2015–present)
• How to.. (2015–present)
• Rich Kids of Instagram (2016)
• Stage School (2016–2017)
• Polterguest (2016–present)^[8]
• Game of Clones (2017)^[9]
• The Crystal Maze (15 November 2020–31 December 2020) (the show moved from its slot on Channel 4 to run-out unaired episodes on E4)

Spin-off from Channel 4 programming edit

• The Jump: On the Piste (2015)

Other previous programming edit

• The 100 (drama)
• 100 Greatest (documentary)
• Accidentally on Purpose (sitcom)
• The Adam and Joe Show (comedy) (moved from Channel 4)
• Agents of S.H.I.E.L.D. (superhero drama) (moved from Channel 4, now moved to Disney+)
• Allen Gregory (animated comedy)
• Almost Royal (comedy-reality)
• As If (comedy-drama)
• Balls of Steel Australia (comedy)
• Banana (drama)
• Banzai (comedy/game show) (now on All 4)
• Bob's Burgers (animated comedy) (moved to Comedy Central after two seasons, now moved to Disney+ for future seasons)
• The Class (sitcom)
• The Cleveland Show (animated comedy) (repeats now on Disney+)
• Clone High (animated comedy)
• Containment (sci-fi drama)
• Gotham (superhero drama) (seasons 4–5 only)
• Desperate Housewives (comedy-drama)
• Dirty Sexy Money (drama)
• Duncanville (animated comedy) (20 October 2021—24 November 2021) (moved from Channel 4 for series two, and later moved to 4Music for series three in 2022)
• The Drew Carey Show (sitcom)
• Empire (drama) (moved to 5Star after three seasons)
• ER (medical drama) (moved to More4 after seven seasons)
• The Event (drama)
• Everwood (drama)
• Father Ted (sitcom) (repeats now on E4 Extra)
• Fonejacker (comedy)
• Franklin & Bash (comedy-drama) (moved to Sony Channel after two seasons)
• Friends (sitcom) (repeats now on Comedy Central)
• Gilmore Girls (comedy-drama) (repeats now on 5Star and Paramount Network)
• Glee (comedy-drama) (moved to Sky One after two seasons)
• Greek (comedy-drama)
• Happy Together (sitcom)
• Hollyoaks Best Bits 2011 (drama)
• Hollyoaks: Chasing Rainbows (drama)
• Hollyoaks Favourites (drama)
• Hollyoaks: In the City (drama)
• Hollyoaks Later (drama)
• Hollyoaks: Let Loose (drama)
• Hollyoaks: A Little Film About Love (drama)
• Hollyoaks: The Good, the Bad and the Gorgeous (drama)
• The Inbetweeners USA (sitcom)
• Jane the Virgin (drama) (after two seasons moved to Netflix, now on ITVBe)
• Kevin Can Wait (sitcom)
• King of the Hill (animated comedy) (repeats moved to 4Music but later disappeared from the schedule on 4Music sometime in 2020 and never aired on UK television again)
• Krypton (sci-fi drama)
• Last Man Standing (sitcom) (moved to 5Star, now moved to Disney+ for the final season)
• Let's Get Physical (sitcom)
• Lost (drama) (moved to Sky One after two seasons)
• Man with a Plan (sitcom)
• The Mindy Project (sitcom)
• My Name Is Earl (sitcom) (now on Disney+)
• Napoleon Dynamite (animated comedy)
• Nashville (drama) (moved to Sky Living after one season)
• The New Normal (sitcom)
• New Girl (sitcom)
• Night Court (sitcom)
• No Angels (comedy-drama)
• The O.C. (drama) (now on ITV2)
• One Tree Hill (drama) (now on ITV2)
• Oz (prison-drama)
• Perfect Couples (sitcom)
• Princess Nikki (reality)
• Queer as Folk (drama)
• Reaper (comedy-drama)
• The Ricky Gervais Show (animated comedy)
• Rock School (documentary/reality, also known as The Samanie & Ellie Programme)
• Rush Hour (comedy-drama)
• Samantha Who? (sitcom)
• School of Rock (music comedy) (now on Nickelodeon and Paramount+)
• Scream Queens (horror comedy-drama) (now on Disney+)
• Scrubs (medical sitcom) (now on Disney+ and E4 Extra)
• The Secret Life of Us (drama)
• Sex and the City (comedy-drama) (now on Sky Comedy)
• Shipwrecked (reality)
• Shameless (comedy-drama)
• Six Feet Under (comedy-drama)
• Smallville (superhero drama)
• The Sopranos (drama) (repeats now on Sky Atlantic)
• Takeover TV (comedy) (moved from Channel 4)
• Taking New York (reality)
• Teachers (comedy-drama)
• Timeless (sci-fi drama)
• Two and a Half Men (sitcom)
• The War at Home (sitcom)
• The West Wing (political-drama) (moved to More4 after four seasons)
• Totally Frank (music/drama about a failed girl band)
• Ugly Betty (comedy-drama)
• What About Brian (comedy-drama)
• Wife Swap UK (reality)
• Wildfire (drama)
• X-Rated: The TV They Tried to Ban (documentary)