Live-action

• Earth 2 (1994–1995)
• Earth 2100 (2009, special, docufiction)
• Earth: Final Conflict (1997–2002)
• Earth Star Voyager (1988, pilot, film)
• Earth vs. the Spider (2001, film)
• Edge of Darkness (1985, UK)
• Eerie, Indiana (franchise):
  • Eerie, Indiana (1991–1992)
  • Eerie, Indiana: The Other Dimension (1998)
• Eleventh Hour (franchise):
  • Eleventh Hour (2006, UK)
  • Eleventh Hour (2008–2009)
• Emerald Soup (1963, UK)
• Encrypt (2003, film)
• Eon Kid aka Iron Kid (2006–2008, South Korea/Spain, animated)
• Escape from Jupiter (1994, Australia)
• Éternelle (2009, France, miniseries)
• Eureka (2006–2012)
• Event, The (2010–2011)
• Exo-Man (1977)^[1] IMDb 
• Expanse, The (2015–2022)
• Extant (2014–2015)
• Extinct (2017)

Animated

• Element Hunters (2009–2010, Japan, animated)
• Ergo Proxy (2006, Japan, animated)
• Eureka Seven (2005–2006, Japan, animated)
• Evil Con Carne (2003–2004, animated)
• Excel Saga (1999–2000, Japan, animated)
• Exosquad (1993–1994, animated)
• Exception (2022, Japan, animated)
• Extreme Dinosaurs (1997, animated)