A Pup Named Scooby-Doo (1988–1991) – Part of the Scooby-Doo franchise. In the series, Scooby and Shaggy are fans of the comic book "Commander Cool and Mellow Mutt." They often dress like the characters in the series.
Bakuman (2008–2012) – Anime series about two teenage manga creators.
Best.Worst.Weekend.Ever. (2018) – A group of teenagers attempt to sneak into a comic book convention to show their homemade comic book to their favorite comic book author.
Big Bad Beetleborgs (1996–1998) – A group of kids are transformed into their favorite comic book superheroes.
The Big Bang Theory (2007–2019) – Most of the main characters are comic book fans. Nearly every episode references comic books.
Bless the Harts (2019–present) – One of the main characters, Violet Hart, is an aspiring artist who makes her own comics.
Blood Ties (2007) – The main protagonist, Henry Fitzroy, works as a graphic novelist.
Bob (1992–1993) – Sitcom about a comic book creator.
The Comic Strip (1987) – Animated series featuring segments of original cartoons in the form of a comic strip.
Con Man (2015–2017) – Web comedy about a struggling actor eking out a living by attending comic book conventions.
Corner Gas (2004–2009) – The main character is an avid comic book fan.
Crazy Fun Park (2023–present) – The main protagonist, Chester, aspires to be a graphic novelist.
Creepshow (2019) – Horror anthology centering on a comic book.
Dark Oracle (2004–2006) – Teen drama centering on a comic book.
Detention (1999–2000) – One of the main characters, Jim Kim, is an obsessed comic book fan. He references comic books in each episode.
Doug (1991–1999) – The main protagonist, Doug, aspires to be a comic book artist. He draws his own comic book featuring his alter-ego, Quilman.
Downtown (1999) – The main protagonist, Alex Hanson, collects comics and toys. He is infatuated with Serena- a goth girl who works at a comic store called Starbase 12.
The Epic Tales of Captain Underpants (2018–present) – Series about two boys who make their own comics. They hypnotize their principal into becoming their comic creation.
Fairly OddParents (2001–2017) – The series features a reoccurring character, the Crimson Chin: a comic book superhero.
Fanboy & Chum Chum (2009–2012) – Animated series about two comic book fans.
Geeking Out (2016) – Series exploring comic books and other forms of nerd culture.
I'm a Virgo – Cootie, the main character, reads comic books based on his favorite superhero, the Hero.
The Imperfects (2022) – One of the main characters, Juan Ruiz, is a graphic novelist.
I Woke Up a Vampire (2023) – Kev, one of the main characters, is a comic fan who works at a comic book store. He uses comics as a source to research supernatural beings.
Kid Cosmic (2020) – Animated series about a comic book fan who becomes a superhero. The format is inspired by comic books.
Kirk (1995–1997) – Sitcom about an illustrator taking care of his family.
The Loud House (2016–present)– The main character, Lincoln Loud, is an avid comic book fan. The series' background art is heavily inspired by comic strips.
My Secret Identity (1988–1991) – The main character, Andrew Clements, is an avid comic fan.
My Wife and Kids (2001–2005) – One of the main characters, Junior, is heavily involved with comic books.
Nerds and Monsters (2014–2016) – Most of the main characters are heavily into nerd culture, including comics. The characters are often seen reading comics.
Once a Hero (1987) – Series about a comic book superhero coming to life.
Project Mc2 (2015–2017) – One of the main characters, Devon D'Marco, is a graphic novelist.
Queer as Folk (2000–2005) – One of the characters, Michael Novotny is an avid comic book fan. He reads comics, attends conventions, and eventually owns a comic store and writes his own comic.
The Real Ghostbusters - (1986–1991) – One of the main characters, Ray Stantz, is a comic book fan. His favorite comic book character is the superhero, Captain Steel, who was featured in two episodes.
Recess (1997–2001) – The main characters are fans of the comic book Senor Fusion.
Re:Creators (2017) – Anime series about comic characters coming to life.
The Replacements (2006–2009) – Two orphans use an ad in a comic book to replace things.
Rocko's Modern Life (1993–1996) – The main protagonist, Rocko, works at a comic book shop.
Roseanne (1988–2018) – Two of the main characters, David Healy and Darlene Conner, were graphic novelists. David was the artist and Darlene was the writer.
Scorpion (2014–2018) – One of the main characters, Sly, reads comics. His favorite comic book is an original character named "Super Fun Guy."
Scream (2015–2019) – Two of the main characters, Noah Foster and Stavo Acosta, are comic fans. Stavo draws his own horror-themed comics. Later, Noah and Stavo partner up to make their own graphic novel.
Supernatural Academy (2022) – One of the main characters, Mischa, is a comic artist. She also has a best friend who is heavily into comics.
The Simpsons (1989–present) – The series features a reoccurring character, Comic Book Guy. He is a comic book collector who owns the local comic book store. He often criticizes and references comic books.
Tear Along the Dotted Line (2021) – Animated sitcom about a cartoonist in Rome and an imaginary armadillo. The series is created by comic artist Zerocalcare.
The Troop (2009–2013) – One of the main characters is an aspiring comic artist.
Utopia (2013–2014) – Sci-fi series centering on a group of fans discovering that their favorite comic book is based on reality.
Woke (2020–2022) – Sitcom about a black comic book artist whose perception on life is changed after being unjustly assaulted by policemen. The series is also based on a comic strip.
Young Sheldon (2017–present) – Two characters, Sheldon Cooper and Tam Nguyen, are comic fans. They shop at a store called "Big City Comix" where Sheldon's sister, Missy, eventually works.
Zero (2021) – Omar, the male lead protagonist, is an aspiring manga artist.
^Torres, Rae (8 March 2023). "'School Spirits' Review: Peyton List Leads a Supernatural Sho Full of Mystery". Collider. Steve Weintraub, Valnet Inc. Retrieved 15 March 2023.