Dumb & Dumber (A 1995 episode of the short-lived animated series entitled "Senseless in Seattle" took place in the city, most notably in the Space Needle)
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Frasier (1993–2004, set in contemporary Seattle. One episode shot on location in Seattle.)
Twin Peaks (1990–1991 TV series and 1992 movie, set in northeast Washington, was filmed in the towns of North Bend and Snoqualmie, about a half-hour outside of Seattle. Seattle is referenced a few times in the series.)