Little Big Adventure 2 has two viewing modes - for indoor scenes it uses a 3D isometric perspective (the game field is rotated 45 degrees) like its predecessor, but for outdoor scenes a 3D perspective view is used. All characters and vehicles are 3D polygon-based objects, allowing for full rotation and movement abilities. The interior game field is divided in scenes (a small block of the game that is active). After completion of certain tasks the player is presented with a full motion video sequence. All text in the game is spoken by the characters. The LBA world is considered extremely large and varied for games of its time. There are three planets to visit, with Twinsun and Zeelich containing their own islands, each with their own unique graphical style. Essentially every character in the game is interactive and will respond differently when Twinsen speaks to them.

Like its predecessor, LBA 2 is real-time adventure. It combines several action game/arcade sequences and some elements from the role-playing game genre. The game's gameplay is partially free-roaming, allowing the player to travel around the islands once they have been "unlocked" by completing certain objectives; there are also many tasks which are optional or non-linear. Certain locations in the game are initially blocked from the player until they progress to a certain stage.

Almost all characters can be talked to, and enemies are often performing tasks while the game world is active.

After Twinsen defeated FunFrock at the end of Little Big Adventure, Twinsun was peaceful, until a sudden storm covered Citadel Island. The Dino-Fly, a creature encountered in LBA is struck by lightning and crashes in Twinsen and Zoe's garden. Twinsen seeks help from Ker'aooc, a healing wizard, who lives on Desert Island, but ferry crossings are cancelled. He aids Bersimon, the island's weather wizard, resulting in the clouds disappearing. After the storm, alien creatures, who call themselves Esmers, land on the planet, under a false diplomatic guise and Twinsen begins training under the Wizard's School after hearing of missing children on the planet. The Esmers use their army to secretly capture Twinsun's Children and openly invite the Wizards to their planet (which is revealed later to be a trap to capture them). After graduating as a wizard, Twinsen is informed by his master of the possible plot of the Esmers and is sent to investigate their planet by accepting their invitation to all Wizards. Once Twinsen lands on Zeelich (the Esmers' two-layered, Venus-like home planet), the invitation proves to be a trap and he is arrested on the landing port. After tricking one of the guards with the help of another prisoner, Twinsen manages to escape imprisonment and escapes the planet in one of the ships. He eventually crashes in the mountains of Citadel Island, where he is attacked by an Esmerian soldier. After defeating him and making his way into the city, he discovers that the Esmers have taken over the planet and have imposed martial law. After going home to check on Zoe he finds out that Baldino has left him a protopack (Prototype Jetpack; it can hover, not fly) in the warehouse, he retrieves it and sets out to find his friend. Once making it to Desert Island he finds out that Baldino has disappeared, he proceeds to investigate his house and discovers that Baldino has built a spacecraft and for some reason went to Emerald Moon (Twinsun's moon). He visits the Wizard's School and learns from his master that in order to proceed in his journey and face the Esmers, who prove to be more than he can handle, he must obtain a powerful artifact from beneath Citadel Island.

Home to several different species, Zeelich is a two-layered planet, the upper layer located above the sea of toxic gas that plagues the planet. The lower layer is located beneath the gas. Its inhabitants await the day when a certain prophecy will be fulfilled, and the Dark Monk, the shadow god, will emerge and restore Zeelich.

Twinsen eventually gathers together four fragments making up a key which must be placed inside a little temple on Celebration Island. He unmasks Dark Monk, who is really FunFrock, the villain from the first game. He kills FunFrock, and returns to stop the moon of Twinsun crashing into the planet.

The music of Little Big Adventure 2 is composed by the French composer Philippe Vachey.

Little Big Adventure 2 sold above 300,000 units by August 1999.^[8][9] GameSpot reported that Twinsen was famous in France, but was an obscure character in USA.^[10]

Robert Coffey of Computer Gaming World said that the game has unparalleled sense of marvel and imagination, engaging story, and deft mix of action and adventure.^[5] GameSpot's Ron Dulin gave the game 8.1 out of 10, saying that the fans of adventure games will not miss this title.^[11] José Dias of Adventure Classic Gaming called Relentless: Twinsen's Adventure an original and intriguing adventure game and gave it a 4 out of 5.^[12]

Next Generation rated it four stars out of five, generally praising the gameplay and the story, and recommended to anyone who love action/adventure games.^[6]

Little Big Adventure 2 was a runner-up for Computer Gaming World's 1997 "Adventure Game of the Year" award, which ultimately went to The Curse of Monkey Island. The editors called Little Big Adventure 2 a "charming" 3D action/adventure hybrid.^[13]

• Little Big Adventure II, a mirror of the original official LBA 2 website.
• Little Big Adventure 2 at MobyGames
• LBA series at Curlie
• Little Big Adventure 2 on GitHub