The East Region was a region that competed in the Little League World Series between 1957 and 2000, until it was split into the Mid-Atlantic and New England regions in 2001.

The East Region was inaugurated in 1957 when the LLWS first gave out Series berths to Regional winners.^[1] The Region initially consisted of teams from Connecticut, Maine, Massachusetts, New Hampshire, New Jersey, New York, Pennsylvania, Rhode Island, Vermont, and two Canadian provinces (Ontario and Quebec). A year later, in 1958, the Canada Region was created and given its own automatic berth In the LLWS. Puerto Rico briefly competed in the East Region, from 1963 through 1967, before moving to the Latin American region. Delaware and Maryland moved to the East Region in 1968; Washington D.C., was given its own spot in the region in 1998.

Little League Baseball expanded the LLWS to sixteen teams for the 2001 Little League World Series. The East Region was split into the Mid-Atlantic Region (Delaware, Maryland, New Jersey, New York, Pennsylvania, and Washington D.C.) and the New England Region (Connecticut, Maine, Massachusetts, New Hampshire, Rhode Island, and Vermont).