Lortalamine (LM-1404) is an antidepressant which was synthesized in the early 1980s.[1][2] It acts as a potent and highly selective norepinephrine reuptake inhibitor.[3][4] Lortalamine was under development for clinical use but was shelved, likely due to the finding that it produced ocular toxicity in animals.[5][6] It has been used to label the norepinephrine transporter in positron emission tomography studies.[4][7][8]
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Routes of administration | Oral |
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Elimination half-life | 5 hours |
Excretion | Renal (98%) |
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Chemical and physical data | |
Formula | C15H17ClN2O2 |
Molar mass | 292.76 g·mol−1 |
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