Luis Mena may refer to:

• Luis de Mena, 18th-century Mexican painter
• Luis Mena (Nicaraguan politician) (Luis Mena Vado, c. 1865–1928), Nicaraguan politician
• Luís Mena e Silva (1902–1963), Portuguese sport equestrian rider
• Luis Rojas Mena (1917–2009), Mexican Roman Catholic bishop
• Luis Mena Arroyo (1920–2009), Mexican Roman Catholic bishop
• Luis Felipe Bravo Mena (born 1952), Mexican politician
• Luis Mena (Chilean footballer) (Luis Mena Irarrázabal, born 1979), Chilean footballer
• Luis Enrique Mena (born 1992), Colombian footballer
• Luis Acosta (footballer) (Luis Acosta Mena, born 1994), Spanish footballer