MIA_PaCa-2 Knowpia

MIA PaCa-2 is a human pancreatic cancer cell line used extensively in pancreatic cancer research and therapy development.^[1]

In 1977,^[2] MIA PaCa-2 cells were derived from the carcinoma of a 65-year-old male.^{[citation needed]}

The cells exhibit CK5.6, AE1/AE3, E-cadherin, vimentin, chromogranin A, synaptophysin, SSTR2, and NTR1, but not CD56.^[1] The cells have a round, epithelial morphology, and are adherent in cell culture.

MIA PaCa-2 has served for decades as a model of pancreatic cancer, and studies of MIA PaCa-2 physiology have helped clarify the mechanisms of carcinogenesis in pancreatic cancer,^[1] aid the development of cancer cell lysates targeting IgG production,^[3] and augmented drug-delivery methods relying on quantum dots.^[4]

References edit

^ ^a ^b ^c Gradiz, Rui; et al. (17 February 2016). "MIA PaCa-2 and PANC-1 – pancreas ductal adenocarcinoma cell lines with neuroendocrine differentiation and somatostatin receptors". Scientific Reports. 6: 21648. Bibcode:2016NatSR...621648G. doi:10.1038/srep21648. PMC 4756684. PMID 26884312.
^ Wu, M; et al. (3 May 1977). "Purification and characterization of a plasminogen activator secreted by cultured human pancreatic carcinoma cells". Biochemistry. 16 (9): 1908–1913. doi:10.1021/bi00628a023. PMID 15590.
^ Taniyama, Kiyomi; Kamiike, Waturu (17 February 2017). Advances in Modern Medicine. Bentham Science Publishers. pp. 117–119. ISBN 9781681080239.
^ Devarajan, Padma V.; Jain, Sanyog (8 December 2014). Targeted Drug Delivery : Concepts and Design. Springer. pp. 596–598. ISBN 9783319113555.

External links edit

Cellosaurus entry for MIA-Paca-2

[rui-1] Gradiz, Rui; et al. (17 February 2016). "MIA PaCa-2 and PANC-1 – pancreas ductal adenocarcinoma cell lines with neuroendocrine differentiation and somatostatin receptors". Scientific Reports. 6: 21648. Bibcode:2016NatSR...621648G. doi:10.1038/srep21648. PMC 4756684. PMID 26884312.

[2] Wu, M; et al. (3 May 1977). "Purification and characterization of a plasminogen activator secreted by cultured human pancreatic carcinoma cells". Biochemistry. 16 (9): 1908–1913. doi:10.1021/bi00628a023. PMID 15590.

[3] Taniyama, Kiyomi; Kamiike, Waturu (17 February 2017). Advances in Modern Medicine. Bentham Science Publishers. pp. 117–119. ISBN 9781681080239.

[4] Devarajan, Padma V.; Jain, Sanyog (8 December 2014). Targeted Drug Delivery : Concepts and Design. Springer. pp. 596–598. ISBN 9783319113555.

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