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MST1R

Summary

Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene.[5][6] MST1R is also known as RON (Recepteur d'Origine Nantais) kinase, named after the French city in which it was discovered. It is related to the c-MET receptor tyrosine kinase.[5][7]

MST1R
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMST1R, CD136, CDw136, PTK8, RON, macrophage stimulating 1 receptor, NPCA3, SEA
External IDsOMIM: 600168 MGI: 99614 HomoloGene: 1835 GeneCards: MST1R
Orthologs
SpeciesHumanMouse
Entrez

4486

19882

Ensembl

ENSG00000164078

ENSMUSG00000032584

UniProt

Q04912

Q62190

RefSeq (mRNA)

NM_001244937
NM_002447
NM_001318913

NM_001287261
NM_009074

RefSeq (protein)

NP_001231866
NP_001305842
NP_002438

NP_001274190
NP_033100

Location (UCSC)Chr 3: 49.89 – 49.9 MbChr 9: 107.78 – 107.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions edit

MST1R has been shown to interact with Grb2.[8][9]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164078 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032584 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Ronsin C, Muscatelli F, Mattei MG, Breathnach R (May 1993). "A novel putative receptor protein tyrosine kinase of the met family". Oncogene. 8 (5): 1195–202. PMID 8386824.
  6. ^ "Entrez Gene: MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase)".
  7. ^ Gaudino G, Follenzi A, Naldini L, Collesi C, Santoro M, Gallo KA, Godowski PJ, Comoglio PM (August 1994). "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP". EMBO J. 13 (15): 3524–32. doi:10.1002/j.1460-2075.1994.tb06659.x. PMC 395256. PMID 8062829.
  8. ^ Li BQ, Wang MH, Kung HF, Ronsin C, Breathnach R, Leonard EJ, Kamata T (November 1995). "Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor". Biochem. Biophys. Res. Commun. 216 (1): 110–8. doi:10.1006/bbrc.1995.2598. PMID 7488076.
  9. ^ Iwama A, Yamaguchi N, Suda T (November 1996). "STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family". EMBO J. 15 (21): 5866–75. doi:10.1002/j.1460-2075.1996.tb00973.x. PMC 452340. PMID 8918464.

Further reading edit

  • Li BQ, Wang MH, Kung HF, et al. (1995). "Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor". Biochem. Biophys. Res. Commun. 216 (1): 110–8. doi:10.1006/bbrc.1995.2598. PMID 7488076.
  • Wang MH, Ronsin C, Gesnel MC, et al. (1994). "Identification of the ron gene product as the receptor for the human macrophage stimulating protein". Science. 266 (5182): 117–9. Bibcode:1994Sci...266..117W. doi:10.1126/science.7939629. PMID 7939629.
  • Gaudino G, Follenzi A, Naldini L, et al. (1994). "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP". EMBO J. 13 (15): 3524–32. doi:10.1002/j.1460-2075.1994.tb06659.x. PMC 395256. PMID 8062829.
  • Lee ST, Strunk KM, Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". Oncogene. 8 (12): 3403–10. PMID 8247543.
  • Collesi C, Santoro MM, Gaudino G, Comoglio PM (1996). "A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype". Mol. Cell. Biol. 16 (10): 5518–26. doi:10.1128/MCB.16.10.5518. PMC 231551. PMID 8816464.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Iwama A, Yamaguchi N, Suda T (1997). "STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family". EMBO J. 15 (21): 5866–75. doi:10.1002/j.1460-2075.1996.tb00973.x. PMC 452340. PMID 8918464.
  • Sakamoto O, Iwama A, Amitani R, et al. (1997). "Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility". J. Clin. Invest. 99 (4): 701–9. doi:10.1172/JCI119214. PMC 507853. PMID 9045873.
  • Follenzi A, Bakovic S, Gual P, et al. (2000). "Cross-talk between the proto-oncogenes Met and Ron". Oncogene. 19 (27): 3041–9. doi:10.1038/sj.onc.1203620. PMID 10871856.
  • Chen YQ, Zhou YQ, Fisher JH, Wang MH (2002). "Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo". Oncogene. 21 (41): 6382–6. doi:10.1038/sj.onc.1205783. PMID 12214279.
  • Chen YQ, Zhou YQ, Fu LH, et al. (2002). "Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantais". Carcinogenesis. 23 (11): 1811–9. doi:10.1093/carcin/23.11.1811. PMID 12419829.
  • Zhou YQ, He C, Chen YQ, et al. (2003). "Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential". Oncogene. 22 (2): 186–97. doi:10.1038/sj.onc.1206075. PMID 12527888.
  • Danilkovitch-Miagkova A, Duh FM, Kuzmin I, et al. (2003). "Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4580–5. Bibcode:2003PNAS..100.4580D. doi:10.1073/pnas.0837136100. PMC 153598. PMID 12676986.
  • Rampino T, Gregorini M, Soccio G, et al. (2003). "The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma". Am. J. Surg. Pathol. 27 (6): 779–85. doi:10.1097/00000478-200306000-00008. PMID 12766581. S2CID 21112098.
  • Penengo L, Rubin C, Yarden Y, Gaudino G (2003). "c-Cbl is a critical modulator of the Ron tyrosine kinase receptor". Oncogene. 22 (24): 3669–79. doi:10.1038/sj.onc.1206585. PMID 12802274.
  • Maggiora P, Lorenzato A, Fracchioli S, et al. (2003). "The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness". Exp. Cell Res. 288 (2): 382–9. doi:10.1016/S0014-4827(03)00250-7. PMID 12915129.
  • Santoro MM, Gaudino G, Marchisio PC (2003). "The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration". Dev. Cell. 5 (2): 257–71. doi:10.1016/S1534-5807(03)00201-6. PMID 12919677.
  • Angeloni D, Danilkovitch-Miagkova A, Miagkov A, et al. (2004). "The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation". J. Biol. Chem. 279 (5): 3726–32. doi:10.1074/jbc.M309342200. PMID 14597639.
  • van den Akker E, van Dijk T, Parren-van Amelsvoort M, et al. (2004). "Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors". Blood. 103 (12): 4457–65. doi:10.1182/blood-2003-08-2713. PMID 14982882. S2CID 8097946.
  • Raeppel S, Gaudette G, et al. (2010). "Identification of a novel series of potent RON receptor tyrosine kinase inhibitors". Bioorg. Med. Chem. Lett. 20 (9): 2745–9. doi:10.1016/j.bmcl.2010.03.073. PMID 20363625.