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MUBII-TB-DB

Summary

MUBII-TB-DB is a database that focuses on tuberculosis antibiotic resistance genes.[1] It is a highly structured, text-based database focusing on Mycobacterium tuberculosis at seven different mutation loci: rpoB, pncA, katG; mabA(fabG1)-inhA, gyrA, gyrB, and rrs.[1][2][3][4][5] MUBII analyzes the query using two parallel strategies: 1). A BLAST search against previously mutated sequences. 2). Alignment of query sequences with wild-type sequences. MUBII outputs graphs of alignments and description of the mutation and therapeutic significance.[1] Therapeutically relevant mutations are tagged as "High-Confident" based on the criteria set by Sandgren et al.[6] MUBII-TB-DB provides a platform that is easy to use for even users that are not trained in bioinformatics.[1]

MUBII-TB-DB
Content
DescriptionA database that documents and tracks tuberculosis antibiotic resistance genes.
Data types
captured		Tuberculosis antibiotic resistance genes
OrganismsBacteria
Contact
Primary citationPMID 24731071
Access
Websiteumr5558-bibiserv.univ-lyon1.fr/mubii/mubii-select.cgi
Miscellaneous
Bookmarkable
entities		yes

See also edit

References edit

  1. ^ a b c d Flandrois, Jean-Pierre; Lina, Gérard; Dumitrescu, Oana (December 2014). "MUBII-TB-DB: a database of mutations associated with antibiotic resistance in Mycobacterium tuberculosis". BMC Bioinformatics. 15 (1): 107. doi:10.1186/1471-2105-15-107. ISSN 1471-2105. PMC 4021062. PMID 24731071.
  2. ^ Heym, B (February 1997). "Multidrug resistance in Mycobacterium tuberculosis". International Journal of Antimicrobial Agents. 8 (1): 61–70. doi:10.1016/s0924-8579(96)00356-1. ISSN 0924-8579. PMID 18611785.
  3. ^ Musser, J M (October 1995). "Antimicrobial agent resistance in mycobacteria: molecular genetic insights". Clinical Microbiology Reviews. 8 (4): 496–514. doi:10.1128/cmr.8.4.496. ISSN 0893-8512. PMC 172873. PMID 8665467.
  4. ^ Almeida Da Silva, P. E.; Palomino, J. C. (2011-07-01). "Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs". Journal of Antimicrobial Chemotherapy. 66 (7): 1417–1430. doi:10.1093/jac/dkr173. ISSN 0305-7453. PMID 21558086.
  5. ^ Zhang, Y.; Yew, W-W. (2015-11-01). "Mechanisms of drug resistance in Mycobacterium tuberculosis: update 2015". The International Journal of Tuberculosis and Lung Disease. 19 (11): 1276–1289. doi:10.5588/ijtld.15.0389. ISSN 1027-3719. PMID 26467578.
  6. ^ Sandgren, Andreas; Strong, Michael; Muthukrishnan, Preetika; Weiner, Brian K; Church, George M; Murray, Megan B (2009-02-10). "Tuberculosis Drug Resistance Mutation Database". PLOS Medicine. 6 (2): e1000002. doi:10.1371/journal.pmed.1000002. ISSN 1549-1676. PMC 2637921. PMID 19209951.