MYO1E Knowpia

MYO1E
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XMF
Identifiers
Aliases	MYO1E, FSGS6, HuncM-IC, MYO1C, myosin IE
External IDs	OMIM: 601479 MGI: 106621 HomoloGene: 55864 GeneCards: MYO1E
Gene location (Human)
Chr.	Chromosome 15 (human)
End	59,372,871 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	70,307,048 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sural nerve; ; gallbladder; ; rectum; ; stromal cell of endometrium; ; ascending aorta; ; right coronary artery; ; islet of Langerhans; ; left coronary artery; ; skin of abdomen;
	Top expressed in
	calvaria; ; left colon; ; lip; ; cumulus cell; ; duodenum; ; epithelium of stomach; ; lacrimal gland; ; left lobe of liver; ; retinal pigment epithelium; ; ascending aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; calmodulin binding; actin filament binding; microfilament motor activity; protein binding; phosphatidylinositol binding; actin binding; cytoskeletal motor activity; ATP binding; lipid binding;
Cellular component	cytoplasm; cell-cell junction; clathrin-coated endocytic vesicle; adherens junction; cell junction; brush border; actin cytoskeleton; extracellular exosome; cytoskeleton; cytoplasmic vesicle; clathrin-coated vesicle; myosin complex;
Biological process	hemopoiesis; endocytosis; glomerular visceral epithelial cell development; glomerular basement membrane development; kidney development; post-embryonic hemopoiesis; in utero embryonic development; actin filament-based movement; vasculogenesis; nitrogen compound metabolic process; glomerular filtration; platelet-derived growth factor receptor signaling pathway; metabolism;
	Sources:Amigo / QuickGO
Orthologs
	4643
	71602
	ENSG00000157483
	ENSMUSG00000032220
	Q12965
	E9Q634
	NM_004998
	NM_181072; NM_025612
	NP_004989
	NP_851417
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin-Ie (Myo1e) is a protein that in humans is encoded by the MYO1E gene.^[5]^[6]

Myosin-Ie is a long tailed myosin. It contains an N-terminal motor domain, an IQ motif, a TH1 domain containing a plecstrin homology (PH) domain, a proline rich TH2 domain, and an SH3 domain. ^[7]

The MYO1E gene was included in several genetic signatures for cancer prognosis.^[8]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000157483 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032220 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, et al. (September 1996). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–439. doi:10.1006/geno.1996.0488. PMID 8884266.
^ "Entrez Gene: MYO1E myosin IE".
^ McConnell RE, Tyska MJ (July 2010). "Leveraging the membrane - cytoskeleton interface with myosin-1". Trends in Cell Biology. 20 (7): 418–426. doi:10.1016/j.tcb.2010.04.004. PMC 2897960. PMID 20471271.
^ Chicco D, Alameer A, Rahmati S, Jurman G (November 2022). "Towards a potential pan-cancer prognostic signature for gene expression based on probesets and ensemble machine learning". BioData Mining. 15 (1): 28. doi:10.1186/s13040-022-00312-y. eISSN 1756-0381. PMC 9632055. PMID 36329531.