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MYO1G 
Summary
Myosin IG, also known as myosin 1G and MYO1G, is a protein that in humans is encoded by the MYO1G gene.[5] MYO1G is a member of class I unconventional myosins. Its expression is highly restricted to hematopoietic tissues and cells. It localises exclusively to the plasma membrane and is dependent on both the motor domain and the tail domain.[6] MYO1G regulates cell elasticity possibly by interaction plasma membrane and cortical actin in Jurkat T-cells.
| MYO1G | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | MYO1G, HA2, HLA-HA2, MHAG, myosin IG | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 600642 MGI: 1927091 HomoloGene: 27996 GeneCards: MYO1G | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function edit
MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010].
References edit
- ^ a b c GRCh38: Ensembl release 89: ENSG00000136286 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020437 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Myosin IG". Retrieved 24 December 2019.
- ^ Olety B, Wälte M, Honnert U, Schillers H, Bähler M (February 2010). "Myosin 1G (Myo1G) is a haematopoietic specific myosin that localises to the plasma membrane and regulates cell elasticity". FEBS Letters. 584 (3): 493–9. doi:10.1016/j.febslet.2009.11.096. PMID 19968988. S2CID 27557093.,
Further reading edit
- Patino-Lopez G, Aravind L, Dong X, Kruhlak MJ, Ostap EM, Shaw S (March 2010). "Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH)". J. Biol. Chem. 285 (12): 8675–86. doi:10.1074/jbc.M109.086959. PMC 2838290. PMID 20071333.
- Larsen ME, Kornblit B, Larsen MV, Masmas TN, Nielsen M, Thiim M, Garred P, Stryhn A, Lund O, Buus S, Vindelov L (October 2010). "Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation". Biol. Blood Marrow Transplant. 16 (10): 1370–81. doi:10.1016/j.bbmt.2010.03.022. PMID 20353833.
- Lio HY, Tang JL, Wu J, Wu SJ, Lin CY, Yang YC (September 2010). "Minor histocompatibility antigen HA-1 and HA-2 polymorphisms in Taiwan: frequency and application in hematopoietic stem cell transplantation". Clin. Chem. Lab. Med. 48 (9): 1287–93. doi:10.1515/CCLM.2010.246. PMID 20509834. S2CID 32914575.
- Sellami MH, Torjemane L, Espadas de Arias A, Kaabi H, Ladeb S, Ben Othman T, Poli F, Hmida S (2010). "Mismatch for the minor histocompatibility antigen HA-2 and GVHD occurrence in HLA-A*0201-positive Tunisian recipients of HSCs". Immunol. Invest. 39 (6): 611–20. doi:10.3109/08820131003775029. PMID 20653428. S2CID 38774267.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.