As a name, it may refer to:

• Margherita Aldobrandini (1588–1646), Duchess consort of Parma
• Margherita de' Medici (1612–1679), Duchess of Parma and Piacenza
• Margherita Maria Farnese (1664–1718), Duchess of Modena and Reggio
• Princess Margherita of Bourbon-Parma (1847–1893)
• Margherita of Savoy (1851–1926), former Queen Consort of Italy and wife of Umberto I
• Margherita, Archduchess of Austria-Este (1930–2022)
• Margherita Bagni (1902–1960), Italian actress
• Margherita Piazzola Beloch (1879–1976), Italian mathematician
• Margherita Boniver (born 1938), Italian politician
• Margherita Buy (born 1962), Italian actress
• Margherita Caffi (1650–1710), Italian painter of still lifes
• Margherita Carosio (1908–2005), Italian operatic soprano
• Margherita Durastanti (fl. 1700–1734), Italian singer
• Margherita Galeotti (1867–after 1912), Italian pianist and composer
• Margherita Gargano (born 1952), Italian middle-distance runner
• Margherita Gonzaga (disambiguation)
• Margherita Granbassi (born 1979), Italian fencer
• Margherita Grandi (1894–1972), Australian-born Italian soprano born Margaret Gard
• Margherita Guidacci (1921–1992), Italian poet
• Margherita Hack (1922–2013), Italian astrophysicist and popular science writer
• Margherita Magnani (born 1987), Italian middle-distance runner
• Margherita Roberti, American operatic soprano whose career began in 1948 and ended in 1988
• Margherita Sarfatti (1880–1961), Italian journalist and mistress of Benito Mussolini
• Margherita Taylor (born 1972), English TV and radio presenter
• Margherita Zalaffi (born 1966), Italian fencer

• Lesli Margherita, American actress
• Pabitra Margherita, Indian politician

• Regina Margherita (disambiguation)
• Santa Margherita (disambiguation)
• Pizza Margherita
• "Felicidad (Margherita)", a song
• Margaret (name)
• Margaret (disambiguation)
• Margarita (disambiguation)