The game uses three full-size flippers, two of which are at the bottom in the normal position while the third is located farther up the table. Other features include two regular-size triangular slingshots at the bottom of the table, along with an 'alive' kickback ball save at the left outlane. There are no under-the-playfield tunnels, however, but the game features two scoops; the Geneva scoop (lower) and the Sarcophagus scoop (upper).

Four pop-bumpers can be found on the left side of the table, near an 'Ice-cave'; a small hole which, when targeted, will give the player a random bonus as well as relighting the alive kickback (if, already, unlit). There is a ramp at the back of the table which feeds the left inlane. Next to that, there is the "North Pole" VUK (Vertical up Kicker) which kicks up into a ramp that feeds the right inlane. The toy in this game is a model of Frankenstein's monster which, during 'Creature Multiball', will throw a ball down onto the playfield.

• The purpose of Mary Shelley's Frankenstein pinball is to finish eight scenes indicated in a circular pattern on the playfield in order to engage a 6-ball multiball wizard mode after finishing all other modes:
• Frankenstein Millions: Shoot all 12 FRANKENSTEIN letters within 30 seconds.
• Stoning: Shoot a total of around 50-60 switches to collect a CREATION letter.
• Creature Feature: The player has 30 seconds to spell CREATURE by shooting the ramp eight times.
• Lynch Justine: Shoot the Left Lane for 3 consecutive hurry-ups.
• North Pole: Shoot the North Pole VUK for a hurry-up starting at 90M.
• Light Extra Ball: Extra ball is lit at the North Pole.
• Voltage Mode: Shoot the ramp for 20M, then the North Pole for 30M, then the Ice Cave for 40M, then the Left Lane for 50M.
• Graveyard: Make a monster by collecting two arms, two legs, a torso, and a head from the various holes.

As well as these modes there are also two separate multiball modes. 'Geneva multi-ball' is a three-ball multi-ball mode and is started by shooting the ball into the 'Geneva' scoop while the Geneva light is activated. 'Creature multiball' is begun by looping the 'Creature ramp' a number of times and then shooting 'North Pole'. This triggers two ball multi-play which can, then, be upgraded to as much as a six ball multi-ball by shooting for the 'North Pole' once again followed by any jackpot shot.

Mary Shelley's Frankenstein has been included as a licensed table in The Pinball Arcade since October 2015. Some Sega logos and the Sonic the Hedgehog cameo were removed, but it retains the song "Frankenstein" by Edgar Winter Group.

The table was also released for Stern Pinball Arcade for free. It included the same changes as in The Pinball Arcade.

• Mary Shelley's Frankenstein at the Internet Pinball Database
• Pinball Archive rule sheet
• The GameRoom Blog: Frankenstein: A Forgotten Monstrous Gem of a Pinball