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Masoprocol

Summary

Masoprocol is an antineoplastic drug used to treat skin growths caused by sun exposure. It is the meso form of nordihydroguaiaretic acid that is taken by mouth. The substance is being studied in the treatment of prostate cancer.

Masoprocol
Clinical data
Trade namesActinex
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration		Topical
ATC code
Pharmacokinetic data
BioavailabilityVery low
Identifiers
  • 4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
CAS Number
  • 27686-84-6 checkY
PubChem CID
  • 71398
IUPHAR/BPS
  • 4265
DrugBank
  • DB00179 checkY
ChemSpider
  • 64490 checkY
UNII
  • 7BO8G1BYQU
ChEBI
  • CHEBI:73468 ☒N
ChEMBL
  • ChEMBL313972 ☒N
CompTox Dashboard (EPA)
  • DTXSID5045178 Edit this at Wikidata
ECHA InfoCard100.044.172 Edit this at Wikidata
Chemical and physical data
FormulaC18H22O4
Molar mass302.370 g·mol−1
3D model (JSmol)
  • Interactive image
  • Oc1ccc(cc1O)C[C@H](C)[C@H](C)Cc2ccc(O)c(O)c2
  • InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+ checkY
  • Key:HCZKYJDFEPMADG-TXEJJXNPSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Masoprocol is also called NDGA, and Actinex.

Mechanism edit

Nordihydroguaiaretic acid is an antioxidant, and it may block certain enzymes needed for tumor growth.

It is a lipoxygenase inhibitor.[1]

References edit

  1. ^ Gowri MS, Azhar RK, Kraemer FB, Reaven GM, Azhar S (September 2000). "Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL". American Journal of Physiology. Endocrinology and Metabolism. 279 (3): E593-600. doi:10.1152/ajpendo.2000.279.3.E593. PMID 10950827.

External links edit

  • MedlinePlus Drug Information
  • Actinex entry in the public domain NCI Cancer Dictionary