Medronic acid

Summary

Medronic acid (conjugate base, medronate), also known as methylene diphosphonate, is the smallest bisphosphonate. Its complex with radioactive technetium, 99mTc medronic acid, is used in nuclear medicine to detect bone abnormalities, including metastases.

Medronic acid
Names
Preferred IUPAC name
Methylenebis(phosphonic acid)
Other names
methanediphosphonic acid; methylene diphosphonate; medronate; phosphonomethylphosphonic acid; MDP
Identifiers
  • 1984-15-2 ☒N
3D model (JSmol)
  • Interactive image
ChEBI
  • CHEBI:43945 ☒N
ChEMBL
  • ChEMBL180570 checkY
ChemSpider
  • 15308 checkY
ECHA InfoCard 100.016.229 Edit this at Wikidata
KEGG
  • D04887 checkY
  • 16124
UNII
  • 73OS0QIN3O ☒N
  • DTXSID8045696 Edit this at Wikidata
  • InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7) checkY
    Key: MBKDYNNUVRNNRF-UHFFFAOYSA-N checkY
  • O=P(O)(O)CP(=O)(O)O
Properties
CH6O6P2
Molar mass 176.001 g·mol−1
Melting point 199 to 200 °C (390 to 392 °F; 472 to 473 K)[1]
Hazards
Lethal dose or concentration (LD, LC):
45-50 mg/kg (i.v., mice, rabbits)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references

References edit

  1. ^ a b Budavari, Susan, ed. (1996), The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (12th ed.), Merck, ISBN 0911910123

External links edit