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Medusavirus

Summary

Medusavirus is a nucleocytoplasmic large DNA virus first isolated from a Japanese hot spring in 2019.[1] It notably encodes all five types of histones — H1, H2A, H2B, H3, and H4 — which are involved in DNA packaging in eukaryotes, raising the possibility that they may have been involved in the origin of eukaryotes.[1] The virus can harden amoebas of the species Acanthamoeba castellanii into stone-like cysts, but infection usually causes infected amoebas to burst open.[2] The virus was named after Medusa, the monster in Greek mythology whose gaze turned people to stone.[2]

Medusavirus
3D reconstruction of the "Medusavirus" particle showcases its thousands of external spikes
Virus classification Edit this classification
(unranked): Virus
Realm: incertae sedis
Kingdom: incertae sedis
Phylum: incertae sedis
Class: incertae sedis
Order: incertae sedis
Family: Medusaviridae Genus: Medusavirus NCLD-viruses edit

Medusavirus is a part of a phylum called Nucleocytoviricota, which is referred as nucleocytoplasmic large DNA virus (NCLDV). These viruses has large double-stranded DNA genome and the length of the genome could be more than 100kb. NCLDV infects various eukaryotic hosts such as amoebas.[3]

Morphology edit

Viral particle is composed of icosahedral capsid which is 260 nm in diameter. This 8 nm single layered capsid is covered with 14 nm spherical-headed spikes. Viral double-stranded DNA is backed inside the 6 nm thick internal membrane.[3]

Maturation edit

Medusaviruses have a unique viral particle maturation process compared to several other viruses. Virus does not form viral factory in the host cytoplasm to replicate the viral genome. The proposed maturation process starts by generating the pseudo-Empty viral particles with the help of scaffold proteins. Then these pseudo-Empty particles release the scaffold proteins and Empty particles are formed. After the release of proteins the Empty particle uptakes the viral DNA near the host nucleus and via semi-Full stages the Full particles are eventually formed.[3]

References edit

  1. ^ a b Yoshikawa G, Blanc-Mathieu R, Song C, Kayama Y, Mochizuki T, Murata K, et al. (April 2019). "Medusavirus, a Novel Large DNA Virus Discovered from Hot Spring Water". Journal of Virology. 93 (8). doi:10.1128/JVI.02130-18. PMC 6450098. PMID 30728258.
  2. ^ a b "The giant Medusavirus turns defenceless cells to 'stone'". Nature. 566 (7745): 429. 2019. Bibcode:2019Natur.566R.429.. doi:10.1038/d41586-019-00591-2. S2CID 71147268.
  3. ^ a b c Watanabe R, Song C, Kayama Y, Takemura M, Murata K (April 2022). Shisler JL (ed.). "Particle Morphology of Medusavirus Inside and Outside the Cells Reveals a New Maturation Process of Giant Viruses". Journal of Virology. 96 (7): e0185321. doi:10.1128/jvi.01853-21. PMC 9006890. PMID 35297671.


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