Mesulergine (INN ) (developmental code name CU-32085) is a drug of the ergoline group which was never marketed.[1][2] It acts on serotonin and dopamine receptors.[3][4] Specifically, it is an agonist of dopamine D2-like receptors and serotonin 5-HT6 receptors and an antagonist of serotonin 5-HT2A, 5-HT2B, 5-HT2C, and 5-HT7 receptors.[citation needed] It also has affinity for the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1F, and 5-HT5A receptors.[5] The compound had entered clinical trials for the treatment of Parkinson's disease; however, further development was halted due to adverse histological abnormalities in rats.[6] It was also investigated for the treatment of hyperprolactinemia (high prolactin levels).[7]
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Other names | CU-32085 |
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UNII |
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Formula | C18H26N4O2S |
Molar mass | 362.49 g·mol−1 |
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