Michael or Mike Wise may refer to:

• Michael Wise (musician) (1648–1687), English organist/composer
• Michael John Wise (1918–2015), British geographer
• Mike Wise (American football) (1964–1992), American football defensive end
• Mike Wise (columnist), American sports columnist and feature writer for The Washington Post
• Mike Wise (politician), former member of the Ohio House of Representatives
• Mike Wise (record producer), Canadian music producer, songwriter, and engineer