Seuphor established a literary magazine, Het Overzicht, in Antwerp in 1921. He moved in Dutch, Belgian, and French avant-garde circles. He associated at various points with Theo van Doesburg and Piet Mondrian, and was influenced by their iconic Neo-plasticist works. Along with Joaquin Torres-Garcia and Pierre Daura, Seuphor founded the abstract artists' group Cercle et Carré. The group, which included luminaries such as Wassily Kandinsky and Le Corbusier.
Seuphor wrote and edited three books; A Dictionary of Abstract Painting (Tudor Publishing Co., 1958), Abstract Painting: 50 Years of Accomplishment (Dell Laurel Edition, 1964), and "The Sculpture of this Century" (George Braziller, Inc. NY, 1960). These volumes, now out of print, remain among the most valuable documents of abstract painting & sculpture in the 20th Century. The painting books have numerous color illustrations which document the various paths that abstract painting took, especially after World War II. The sculpture book has black & white photos that track both figurative as well as abstract sculpture from early 20th century through 1959. Also contains a short bio in the back of the book on each sculptor mentioned.
Seuphor also assisted with the Tudor companion volume of his Dictionary of Abstract Painting, the Dictionary of Modern Painting, which documents all the various schools of painting in the 20th Century, including both abstract and realist painting.