Gold entered the comic industry as DC's first public relations manager. His job was to improve DC's interactions with the direct market and comic fans.^[2]

Gold launched First Comics in 1983 with a line-up of creators including Frank Brunner, Mike Grell, Howard Chaykin, Joe Staton, Steven Grant, Timothy Truman, and John Ostrander. Among the titles Gold edited were Chaykin's satirical futuristic cop series American Flagg; Ostrander and Truman's GrimJack; Mike Baron and Steve Rude's Nexus; Badger; Jim Starlin's space opera series Dreadstar and Mike Grell's Jon Sable Freelance,^{[3][failed verification]} which was briefly adapted for TV.

In 1986, Gold left First Comics and returned to DC, where he edited Legends, The Shadow, The Question, Action Comics Weekly, Green Arrow: The Longbow Hunters, Blackhawk, and Hawkworld.^{[4][failed verification]}

In 2005, Gold revived Jon Sable Freelance and GrimJack for IDW Publishing with new miniseries and reprint collections of the First Comics issues, and would also publish a complete collection of Mars.

In 2006, Gold co-founded ComicMix with Brian Alvey and Glenn Hauman.

In 2011, he received the first Humanitarian Award from the Hero Initiative during the Harvey Awards ceremony at the Baltimore Comic-Con.

Gold has worked with the Organic Theater Company of Chicago and the American Shakespeare Theatre, been involved with numerous political efforts, and a significant contributor to an award-winning Head Start and early childhood education program for the Child Care Center of Stamford. His writings have appeared in a wide range of newspapers and magazines, including The Chicago Tribune, The Realist and MacUser magazine.

• ComicMix
• Articles by Mike Gold on ComicMix