Mayama made film and television appearances from the mid 1960s to the late 1970s. She had a supporting role in Hey Landlord! (1966); her guest appearances on series television include Valentine's Day (1965), I Spy (1966), Star Trek (1967), It Takes a Thief (1968), The Beverly Hillbillies (1971), Ironside (1971), Medical Center (1971-1972), Hawaii Five-O (1972), Kojak (1974), Mannix (1974), and M*A*S*H (1979).

Her films include Impasse (1969), The Hawaiians (1970), Amanda Fallon (1973), That Man Bolt (1973) and Cage Without a Key (1975).

Mayama met Burt Reynolds in 1968 while working in Japan as a kabuki theater player.^{[dubious – discuss]} Reynolds was in Japan to film Impasse and Mayama signed on to the cast. They lived together from 1968 to 1971. She learned English by watching Bugs Bunny cartoons, according to Reynolds' autobiography But Enough About Me.^[1]

• 1965: Valentine's Day (Television series, a sequence)
• 1965: Wendy and Me, a consequence (TV series)
• 1965: Boeing Boeing
• 1966: I Spy (I Spy, the TV series, a consequence)
• 1966: Walk, Don't Run (Walk Don't Run)
• 1966: Hey, Landlord (TV series)
• 1967: F Troop (TV series), From Karate with Love
• 1967: Star Trek (episode: "A Taste of Armageddon", character: Yeoman Tamura)
• 1967: The War Wagon (The War Wagon)^[2]
• 1968: It Takes a Thief, the TV series, a sequence
• 1969: Impasse
• 1969: Love, American Style (TV series)
• 1969: The Courtship of Eddie's Father
• 1970: The Flying Nun, a consequence (TV series)
• 1970: The Hawaiians^[3]
• 1970: Matt Lincoln (TV series), a sequence
• 1971: To Rome with Love (TV series)
• 1971: The Beverly Hillbillies, a sequence, three episodes (TV series)
• 1971: Ironside (1967 TV series) (Ironside, the TV series, a consequence)
• 1971-1972: Medical Center (TV series), two consequences
• 1972: Hawaii Five-O (1968 TV series) Hawaii Five (Hawaii Five-O, the TV series, a consequence)
• 1973: The Bold Ones: The New Doctors (TV series), a sequence
• 1973: Amanda Fallon (TV movie)
• 1973: That Man Bolt
• 1974: Kojak (Kojak, the TV series, a consequence)
• 1974: Mannix (TV series), a sequence
• 1975: Cage Without a Key (TV movie)
• 1979: M*A*S*H (television series, episode 7-18)

• Miko Mayama at IMDb  
• Miko Mayama at AllMovie