Mills Creek may refer to:

• Mills Creek (Missouri), a stream in Missouri
• Mills Creek, a San Francisco Bay Area stream with mouth at Arroyo León (37°26′46″N 122°24′19″W / 37.4460518°N 122.4052519°W / 37.4460518; -122.4052519^[1])
• Mills Creek, a California stream with headwaters on the Sierra Crest at the Mills Creek cirque (37°20′56″N 118°47′12″W / 37.348872°N 118.786583°W / 37.348872; -118.786583)
• Mills Creek (San Mateo County), a stream flowing through Burlingame to the San Francisco Bay