The ministry is responsible for Islamic religious affairs and the administration of endowments.^[2]

• Abd al-Rahman al-Kayyali (14 October 1944 – 1 April 1945)
• Said al-Ghazzi (7 April 1945 – 16 August 1945)
• Youssef Muzahim (17 March 1960 – 28 September 1961)
• Ahmed Sultan (29 September 1961 – 21 November 1961)
• Mustafa Al-Zarqa (22 November 1961 – 15 April 1962)
• Rashid Humaidan (16 April 1962 – 16 September 1962)
• Asaad Al-Kourani (17 September 1962 – 9 March 1963)
• Darwish Al-Alwani (9 March 1963 – 31 March 1963)
• Mazhar Al-Anbari (1 April 1963 – 30 April 1963)
• Ahmed Mahdi Al-Khidr (1 May 1963 – 12 April 1963)
• Abdul Rahman Al-Tabbaa (13 May 1963 – 10 February 1964)
• Abdul Rahman Al Kawakibi (13 May 1964 – 31 December 1965)

• Mohammed Ghaleb Abdoun (16 January 1966 – 4 April 1971)
• Abdul Sattar Khair al-Din al-Asadi (4 April 1971 – 13 January 1980)
• Mohammed al-Khatib (14 January 1980 – 30 October 1987)
• Abdel Majid Trabelsi (1 November 1987 – 7 February 1996)
• Mohammed Abdul Raouf Ziada (7 April 1996 - 3 October 2004)
• Ziyad al-Din al-Ayyubi (3 October 2004 – 7 December 2007)
• Mohammed Abdul Sattar (8 December 2007 – incumbent)^[3]

• Government ministries of Syria
• Cabinet of Syria