The Ministry is headed by the Minister of Interior, who is appointed by the President of Ghana and is approved by the Ghana Parliament after a vetting process. The current Minister of Interior is Henry Quartey since 14 February 2024.

In order to ensure the proper functioning of the Ministry, it has it functions being divided into seven major objectives. These are aimed at achieving the wholist purpose of the Ministries aim of maintaining internal peace:^[1]

1. Ensure adequate protection of life and property.
2. Ensure effective and efficient crime prevention and detection.
3. Strengthen disaster prevention, management and social mobilisation.
4. Regulate and monitor the entry, stay and exit of nationals of all countries.
5. Develop a highly efficient and humane custodial and reformatory system.
6. Improve institutional capacity.
7. Improve the public relations system.

The Ministry of Interior being the government's chief agency in charge of maintenance and enforcement of Internal Law and Order has agencies under it that have specific functions aimed at achieving the overall purpose of the Ministry and the country as a whole. The Institutions through which the Ministry performs its functions are:^[2]To achieve its mandate and objectives, the Ministry operates through ten (10) Agencies:

• Ghana Police Service
• Ghana Prisons Service
• Ghana National Fire Service
• Ghana Immigration Service
• Narcotics Control Commission
• National Disaster Management Organization
• Gaming Commission of Ghana
• National Commission on Small Arms and Light Weapons
• National Peace Council
• Ghana Refugee Board
• Interior Headquarters