MS 245 is located in Lowndes,^[5] Chickasaw,^[6] and Lee counties.^[7] The route is legally defined in Mississippi Code § 65-3-3,^[8] and it is maintained by Mississippi Department of Transportation (MDOT) as part of the Mississippi State Highway System.^[1]

In Lowndes County, MS 245 starts at its intersection with US 45 Alt., and it begins traveling northwestwards. After passing through a small area of trees, the road intersects Main Street and Tarlton Road, entering the city limits of the town.^[5] It then passes under a railroad and enters the outskirts of Crawford. MS 245 intersects multiple streets as it turns north towards US 45 Alt.. North of Long Street, the road begins to bend northeastwards, and it soon ends at US 45 Alt.^[2]

In Chickasaw County, MS 245 starts at US 45 Alt. south of Egypt.^[6] The road begins traveling northwestwards through farmland, intersecting County Roads 410 and 155 (CRD 410 and CRD 155, respectively). North of CRD 252, the route crosses Jolly Creek.^[3] MS 245 turns north at CRD 149 and enters Okolona at Filgo Road.^[9] Inside the city, the road is known as Church Street, and it enters travels through the residential areas around it. MS 245 meets MS 41 and the western terminus of MS 32 at Monroe Avenue. North of Okolona Elementary School, the road intersects Main Street, which leads to downtown Okolona.^[3] On the northern side of the city, MS 245 intersects the entrance to Okolona High School,^[3] and it leaves the city limits north of Rasberry Drive.^[9] The road turns northeastwards at that point, and it begins traveling through farmland.^[3] South of CRD 136, the route crosses over Tallabinnela Creek, and it enters Lee County at CRD 139.^[6] The road crosses the Tubbalubba Creek north of the intersection, and Chiwapa Creek north of CRD 506.^[7] Past Chiwapa Creek, MS 245 enters Shannon,^[10] and it is known as Romie Hill Avenue. The road intersects the entrance of Shannon Elementary School at Mobley Street. The route ends at MS 145 (Noah Curtis Street), and the road continues as MS 145.^[3]

The sections that became part of MS 245 were previous part of several older designations. The first two designations, MS 23 and MS 25, were given by 1932, for a gravel road from Starkville to Shannon, and a gravel road from Macon to Tennessee–Mississippi state line, respectively.^[11][12] The section of MS 23 from Okolona to Shannon was paved by 1937.^[13][14] By 1939, the section of MS 25 from Brooksville to Mayhew was paved.^[15][16] Both designations were replaced by MS 45W around 1940.^[16][17] MS 45W was renumbered to US 45 Alt. by 1968.^[18][19]

In 1998, a bypass around Okolona was opened, and US 45 Alt. was rerouted onto the newly constructed divided highway. This was planned as part of the 1987 Four-Lane Highway Program, and the section cost $18.7 million.^[20] MS 245 was the designation for US 45 Alt.'s old alignment, from Okolona to Shannon.^[21][22] In 2007, more parts of US 45 Alt. were upgraded to a four-lane highway,^[23] and Crawford was bypassed as a result.^[24][25]

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