Monica Rappaccini debuted in Amazing Fantasy vol. 2 #7 (2005),^[3] created by Fred Van Lente and Leonard Kirk.^[4] She appeared in the 2007 Super-Villain Team-Up MODOK's 11 series.^[5] She appeared in the 2017 The Unstoppable Wasp series.^[6] She appeared in the 2020 Ravencroft series.^[7]

Monica Rappaccini went to New Mexico's Desert State University to study and shared a brief relationship with physics student Bruce Banner while enrolled as a biochemistry student at the University of Padua. She used their relationship to exploit Banner's radiation expertise for her own research. Upon attaining her doctorate, Rappaccini quickly became a world-renowned innovator of antitoxins and antidotes for various environmental poisons and nearly won a Nobel Prize.^[8]

Recognizing the many environmental and political failings of Western civilization, Rappaccini decided that it was too corrupt to exist. She joined a series of terrorist organizations, such as the pan-European leftist group the Black Orchestra, and then Advanced Idea Mechanics (A.I.M.), where she had a brief relationship with fellow agent George Tarleton.^[9] Making poisons instead of curing them, Rappaccini's expertise with toxins allowed her to rise quickly through A.I.M.'s ranks. She implanted her own daughter and several other newborn children of A.I.M. members with memetic antibodies. She released them into the world as A.I.M. Waker agents with no knowledge of their heritage. They programmed to travel instinctively to the nearest A.I.M. biohaven when their antibodies activated at age 16. Her daughter was raised in Vermont by undercover A.I.M. agents as Carmilla Black.^[10]

Monica Rappaccini went underground for nearly two decades and studied potential power sources such as the sentient Uni-Power. She orchestrated attacks on capitalism, such as the dioxin-based gas attack on Hong Kong. When the A.I.M. Scientist Supreme was slain by renegade A.I.M. creation MODOK, Rappaccini became head of a splinter faction of A.I.M. that remained independent from MODOK's control. Following his numerous defeats, Rappaccini's splinter group absorbed more cells into a sizable rival faction. She was made Scientist Supreme of this "true" version of A.I.M.^[11] She rarely did field work as A.I.M.'s leader, preferring to act through agents and proxies.

When she led an A.I.M. attack on the United States Army Medical Research Institute for Infectious Diseases, it was thwarted by her estranged 19-year-old daughter, who had since joined forces with S.H.I.E.L.D. and became the costumed superheroine the Scorpion II. Monica Rappaccini eluded capture and soon attempted to harness the malfunctioning Uni-Power, but her plans were thwarted by the Scorpion II and several superheroes who bonded with the Uni-Power.^{[volume & issue needed]}

Her A.I.M. faction was involved in an A.I.M. civil war against MODOK's faction that drew in several of the Marvel superheroes, prominent among were Ms. Marvel^[12] and the Hulk.^[13] Following Ms. Marvel's thwarting of a plan to turn MODOK into a bomb, Rappaccini reunited the organization under her control.^[14]

She infiltrated the supervillain group MODOK's 11 with A.I.M.'s new robot the Ultra-Adaptoid, which was impersonating the Chameleon. She attempted to prevent MODOK from obtaining a weapon called the Hypernova and using it to erase all life on Earth. She had a stated aim to stop A.I.M. from creating "inventions that turn around and try to destroy us." In the end, MODOK gained the Hypernova, and Monica gave him $1 billion dollars in exchange for it - which, unknown to her, had been MODOK's plan all along, as he had already worked out that the Hypernova would grow unstable and explode anyway. A.I.M.'s base was destroyed in the explosion and MODOK believed Monica was dead.^[15]

During the "Dark Reign" storyline, it is revealed that Rappaccini survived and came into conflict with Mockingbird and Ronin.^[16] She also hired Deadpool to retrieve a batch of baby M.O.D.O.C.'s enhanced to warp reality from H.A.M.M.E.R. headquarters.^[17]

After a failed attempt to persuade Hank Pym to join A.I.M., she and her followers were stranded on Earth-Charnel when the Wasp deactivated her facility's dimensional screen.^[18]

Monica and A.I.M. later sided with Norman Osborn after he escaped from prison and reformed H.A.M.M.E.R.^[19] Following Osborn's defeat, she and A.I.M. end up retreating.^[20]

During the Avengers vs. X-Men storyline, Noh-Varr located a secret A.I.M. base where Rappaccini and the A.I.M. agents that escaped following Osborn's defeat were hiding out. The Avengers raided the base and arrested Monica and the other A.I.M. members that were present at the time.^[21]

She then escaped from prison and fought the new Wasp. Monica Rappaccini was later seen as a member of J.A.N.U.S.^[22]

Monica Rappaccini is an expert in robotics, chemistry, physics, engineering, biotoxins, and biochemistry.^[23] Her inventions include the enhanced lymphatic system of the A.I.M. Waker agents that granted them total immunity to all biological, chemical and radiological weapons, memetic antibodies, synthetic microbes that attack the human psyche and trigger pre-coded memories and impulses, hallucinogenic drugs that deliver programmed hallucinations before being absorbed into the system; and many innovative weapons of mass destruction, from gas attacks to nanobacterial bombs.

Her A.I.M. uniform belt contains a phasing device that allows her to teleport.^[24] She keeps many different devices at hand, varying upon her situation and opponent. When facing a captured Hank Pym, she boasts that she kept 157 methods of containing him on hand.^[18]

Melody MacReady of Screen Rant called Monica Rappaccini one of the "most ruthless villains of the Marvel Universe," writing, "Monica is manipulative, prejudiced, murderous, and proud of what she does; this was best shown when she was one of the best villains in the game Marvel's Avengers."^[25]

House of M edit

An alternate version of Monica Rappaccini appears in the "House of M" storyline.^[26] She worked alongside the Scorpion II and the Hulk to overthrow Governor Exodus' fascist mutant government in Australia when Scarlet Witch reality-warped Earth into a mutant-dominated society,. When the Hulk became Australia's new leader, she secret plan to create a cybernetic army to overthrow Earth's mutant rulers was exposed. Denying any knowledge of the army, she promised to restore the cyborgs' humanity. When this warped reality was undone, the disoriented Rappaccini found herself stranded in Australia alongside Bruce Banner. Evading the Scorpion II's attempt to arrest her, Rappaccini returned to A.I.M.

Death's Head 3.0 (Earth-6216) edit

An alternate version of Monica Rappaccini appears in the alternate future timeline in Death's Head 3.0. She created the Uni-Alias, an artificial variant of Captain Universe's Uni-Power.^[27] Decades later her granddaughter Varina Goddard, a Senior Scientist in the future A.I.M., used the Uni-Alias as a power source for the Death's Head robot in her attempt to assassinate the United Nations Secretary General.

Ant-Man: Natural Enemy edit

An alternate version of Monica Rappaccini appears in the Ant-Man: Natural Enemy. She captures the shrunken Scott Lang and was going to make her pet, but later attempts to kill Lang by flushing the latter down the toilet. It is revealed that Rappaccini murdered animals when she was a child, especially ants.

Television edit

• Monica Rappaccini / Scientist Supreme appears in Spider-Man, voiced by Grey DeLisle.^[28] This version oversees the organization's front at the Bilderberg Academy boarding school by posing as its headmistress.
• Monica Rappaccini / Scientist Supreme appears in M.O.D.O.K., voiced by Wendi McLendon-Covey.^[29] This version is an A.I.M. scientist and work rival of the titular character.^[30] Additionally, she has a teenage daughter named Carmilla who was the result of Monica creating a male clone named "Manica" and having him inseminate her. Introduced in the episode "If Bureaucracy Be Thy Death!", it is revealed that she once greatly admired MODOK and applied for A.I.M. to work together, but she developed a hatred after MODOK took credit for her killing a major yet unnamed member of the Avengers. Complicating this however, she later realizes that MODOK supports her endeavors and put her in a higher position so she can continue her work. After A.I.M. goes bankrupt and is bought out by GRUMBL, the latter promotes Monica to Scientist Supreme, but limits her work. By the end of the series, MODOK convinces her to leave A.I.M., though she decides to continue working for MODOK at his new company, A-I-M-2.

Video games edit

• Monica Rappaccini / Scientist Supreme appears in Marvel Powers United VR, voiced by Jennifer Hale.
• Monica Rappaccini / Scientist Supreme appears in Marvel Strike Force.^[31]
• Monica Rappaccini / Scientist Supreme appears in Marvel's Avengers, voiced by Jolene Andersen.^[32] This version serves as a senior executive of A.I.M. She assists Dr. George Tarleton in efforts to control the growing Inhuman population while also acting as a personal caretaker after Tarleton was mutated due to exposure to a Terrigen crystal, but Rappaccini's injections administered were derived from Captain America's blood and accelerated Tarleton's mutation instead.^[33] Tarleton injects Rappaccini with it and leaves her for dead. In a mid-credits scene however, Rappaccini survived after transplanting an Inhuman's duplication ability to herself off-screen. Following Tarleton's defeat at the hands of the Avengers, she takes over A.I.M. as Scientist Supreme and meets with the organization's board of directors, vowing to renew A.I.M. experiments and develop new technology.^[34]
  • In the DLC expansions "Taking A.I.M.", "Future Imperfect", "Cosmic Cube", "War for Wakanda" and "No Rest for the Wicked", she leads A.I.M. in building a time gate to work with Nick Fury, Hawkeye, and her future self to avert a Kree invasion. She creates the Cosmic Cube to stop the aliens, but is freezes her and everyone around her in time while the rest of the world falls into chaos. Meanwhile, a clone of the present Rappaccini continues working on the Cosmic Cube until the Avengers and Hawkeye's future self intervene to stop her from destroying reality, with the latter sacrificing himself and killing Rappaccini to do so. Despite this, another clone of Rappaccini hires Ulysses Klaue and Crossbones to help her invade Wakanda for its Vibranium and leading scientists. However, Klaue kills most of the scientists in pursuit of his own goals, leading to Rappaccini cutting ties with Klaue and leading A.I.M. in a separate attack on Wakanda. Due to the Avengers' work in dismantling A.I.M., the desperate Rappaccini revives Tarleton to preserve the organization, but he kidnaps her instead.

• Monica Rappaccini on Marvel Database, a Marvel Comics wiki