In music, monophony is the simplest of textures, consisting of melody without accompanying harmony.

Monophony or monophonic may also refer to:

• Monophony (Russian Orthodox liturgy), consecutive singing of chants one by one, as opposed to simultaneous singing
• Monaural, single-channel sound reproduction, also known as monophonic sound reproduction
• Monophonic synthesizer, a synthesizer that produces one note at a time, also known as monosynth