In enzymology, a monosialoganglioside sialyltransferase (EC 2.4.99.2) is an enzyme that catalyzes the chemical reaction
monosialoganglioside sialyltransferase | |||||||||
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Identifiers | |||||||||
EC no. | 2.4.99.2 | ||||||||
CAS no. | 60202-12-2 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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The 2 substrates of this enzyme are CMP-N-acetylneuraminate and D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide, whereas its 2 products are CMP and N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide.
This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-ac etylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetylneuraminyltransferase.