The 'Simbruini' name derives from Simbruvium, a lake formed by the river Anio, situated in the territory of the Aequi; it may derive from Latin sub imbribus ("under the rain"). They are also popularly known as "Rome's Alps".
The Monti Simbruini mark a part of the border between Abruzzo and Lazio. The Monti Simbruini border with the Monti Cantari and the Carseolani Mountains. The range's highest peak is Monte Cotento, at 2,015 metres (6,611 ft) in elevation.
On the Lazio side of the mountain range, between the provinces of Rome and Frosinone, a natural park has been established, the Parco naturale regionale Monti Simbruini.
The Regional Park of the Monti Simbruini, which also includes the Monti Cantari range, was established in 1983.  It has an area of 300 square kilometres (120 sq mi).
Habitats in the Monti Simbruini include: the Apennine deciduous montane forests ecoregion, in the temperate broadleaf and mixed forests biome; and the Italian sclerophyllous and semi-deciduous forests ecoregion, in the Mediterranean forests, woodlands, and scrub biome.
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