Moselle is a river in France, Luxembourg and Germany.

Moselle may also refer to:

• Moselle (department), French département surrounding the river
• Moselle (riverboat), American 19th-century riverboat
• Moselle wine from the region around the river
• River Moselle (London), England
• Moselle, Mississippi, unincorporated community in the United States
• Moselle, Missouri, unincorporated community in the United States
• Mosel, Wisconsin, township in the United States, sometimes spelled Moselle and named after the river
  • Mosel, Wisconsin, unincorporated community in the above township
• Open de Moselle, ATP tennis tournament