Mount de Sales Academy has been named one of the top 50 Catholic schools in the country by the Catholic High School Honor Roll each year since 2004 on the basis of academics, Catholic identity, and civic education [1]. It is the only school in the state of Maryland to be included in the list.

Mount de Sales is located on 12 acres (49,000 m²) of land, from which one can see the Inner Harbor and the Baltimore city skyline. The back yard of the school is home to a garden featuring a statue of the Blessed Virgin Mary. The campus also includes the Center for Performing Arts and Student life (opened in 2021), athletic fields, a convent, and a gymnasium.

Most classes are still held in the original school building, begun in 1852 and expanded in the 1860s. The main building, which is listed on the National Register of Historic Places, retains architectural traces of the cloistered sisters of the Visitation Order who founded the school.^[4] The chapel, located in the center of the main building, is the oldest place of worship still in use in Baltimore. The stained glass windows in the chapel, original to the building, were cast in the same place and manufacturing technique as the famous stained glass of the Cathedral of Chartres, France. The windows are located at the back of the building, as Catholics in the area were undergoing much persecution at the time of the building's planning, and its founders wished to avoid vandalism and protest. The building also includes the Music Hall, which has details such as trompe-l'œil painting and is where graduation is held annually, the Padre Pio library, which contains relics of that saint and a mosaic in his honor, computer labs, a spacious art studio, the Ramona Carrigan Science Center, research lab, and newly added STEM and robotics rooms.

The Regina Keenan Knott Alumnae Hall was formerly an infirmary for the school's boarding students. At one time it was connected to the main building by a walkway which has since been demolished. The building's front is the opposite of the main building so that visitors would not see any of the sick or otherwise ailing girls. The building now houses the school's development and alumnae relations groups.

The Constance and Samuel Pistorio Sports Complex was dedicated in 1999. Its design was modeled after the architecture of the campus' historic buildings. The facility is located across from the main building, on a piazza featuring gardens and a bronze statue of Saint Joseph the Worker.

The Center for Performing Arts and Student Life, a 24,000-square foot building that opened in 2021, features music and dance classrooms, practice rooms for student performers, fully equipped scene shop and storage space for technical theatre students, 400-seat fixed lower-level orchestral section, 200-moveable seat upper-level multi-use space, and control room for audio, lighting, and visual equipment.

The nearby all-boys Mount Saint Joseph High School is the Brother School of Mount de Sales Academy. The two schools share their long history with each other. In the present day:

• The schools jointly produce theatrical events
• The schools cooperate on bus service
• Sailor cheerleaders support Gaels' sporting events
• The schools hold joint social events such as dances
• The schools share many school clubs

• Nicolette Jennings, Miss Florida USA 2019^[5]
• Brigid Kemmerer, young adult author
• Audrey Powers, Vice President of Mission and Flight Operations of American aerospace and spaceflight company Blue Origin.

•  
  Chapel of St. Francis de Sales at Mount de Sales
•  
  Class photo at graduation on the front steps of the main building
•  
  The Music Hall
•  
  The Main Building

• National Catholic Educational Association

• Official website
• Roman Catholic Archdiocese of Baltimore